US2007060542A9PendingUtilityA9

Method for preventing vascular disease

61
Individually held — no corporate assignee on recordPriority: Dec 29, 1992Filed: Dec 4, 2002Published: Mar 15, 2007
Est. expiryDec 29, 2012(expired)· nominal 20-yr term from priority
Inventors:Robert H. AllenSally P. Stabler
A61K 31/714A61K 31/525
61
PatentIndex Score
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Cited by
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Claims

Abstract

A method for orally administering vitamin preparations is described which combine vitamin B 12 (B 12 , cobalamin) and folic acid (folate), with and without pyridoxine (B 6 ), for preventing and treating elevated serum homocysteine (HC), cystathionine (CT), methylmalonic acid (MMA), or 2-methylcitric acid (2-MCA) levels. These metabolites have been shown to be indicative of B 12 and/or folic acid deficiencies. Further, it is likely that a B 6 deficiency may be present with a B 12 or folate deficiency. The method of the invention is also for use in lowering serum HC, CT, MMA, or 2-MCA in patients with or at risk for neuropsychiatric, vascular, renal or hematologic diseases. The method of the present invention eliminates the costly and time consuming steps of distinguishing between vitamin deficiencies once a deficiency is found by measurement of serum metabolite levels. The present invention is of particular benefit to the populations at risk for elevated serum metabolite levels, such as the people over the age of 65, and populations that have or are at risk for neuropsychiatric, vascular, renal and hematologic diseases.

Claims

exact text as granted — not AI-modified
1 . A method of preventing vascular disease in a human, comprising periodically administering orally a single formulation having between 0.3 and 10 mg vitamin B 12  and 0.1 and 0.4 mg folic acid.  
   
   
       2 . The method of  claim 1  wherein the formulation includes approximately 2 mg vitamin B 12  and 0.4 mg folic acid.  
   
   
       3 . The method of  claim 1  wherein said vascular disease is cardiovascular disease.  
   
   
       4 . The method of  claim 1  wherein said vascular disease is stroke.  
   
   
       5 . The method of  claim 1  wherein said vascular disease is peripheral vascular disease.  
   
   
       6 . The method of  claim 1  wherein said vascular disease is associated with renal disease.  
   
   
       7 . A method of preventing vascular disease in a human, comprising periodically administering orally a single formulation having between 0.3 and 10 mg vitamin B 12,  and 0.1 and 0.4 mg folic acid, and 5 and 75 mg vitamin B6.  
   
   
       8 . The method of  claim 7  wherein the formulation includes approximately 2 mg vitamin B12 and 0.4 mg folic acid and 25 mg vitamin B6.  
   
   
       9 . The method of  claim 7  wherein said vascular disease is cardiovascular disease.  
   
   
       10 . The method of  claim 7  wherein said vascular disease is stroke.  
   
   
       11 . The method of  claim 7  wherein said vascular disease is peripheral vascular disease.  
   
   
       12 . The method of  claim 7  wherein said vascular disease is associated with renal disease.  
   
   
       13 . A method of preventing vascular disease in a human, comprising periodically administering orally a single formulation having between 0.3 and 10 mg vitamin B12 and 0.4 and 10.0 mg folic acid.  
   
   
       14 . The method of  claim 13  wherein the formulation includes approximately 2 mg vitamin B12 and 1.0 mg folic acid.  
   
   
       15 . The method of  claim 13  wherein the formulation includes approximately 2 mg vitamin B12 and 2.0 mg folic acid.  
   
   
       16 . The method of  claim 13  wherein the formulation includes approximately 2 mg vitamin B12 and 2.5 mg folic acid.  
   
   
       17 . The method of  claim 13  wherein the formulation includes approximately 1 mg vitamin B12 and 2.0 mg folic acid.  
   
   
       18 . The method of  claim 13  wherein the formulation includes approximately 1 mg vitamin B12 and 2.5 mg folic acid.  
   
   
       19 . The method of  claim 13  wherein said vascular disease is cardiovascular disease.  
   
   
       20 . The method of  claim 13  wherein said vascular disease is stroke.  
   
   
       21 . The method of  claim 13  wherein said vascular disease is peripheral vascular disease.  
   
   
       22 . The method of  claim 13  wherein said vascular disease is associated with renal disease.  
   
   
       23 . A method of preventing vascular disease in a human, comprising periodically administering orally a single formulation having between 0.3 and 10 mg vitamin B12, and 0.4 and 10 mg folic acid, and 5 and 75 mg vitamin B6.  
   
   
       24 . The method of  claim 23  wherein the formulation includes approximately 2 mg vitamin B12 and 1.0 mg folic acid and 25 mg vitamin B6.  
   
   
       25 . The method of  claim 23  wherein the formulation includes approximately 2 mg vitamin B12 and 2.0 mg folic acid and 25 mg vitamin B6.  
   
   
       26 . The method of  claim 23  wherein the formulation includes approximately 2 mg vitamin B12 and 2.5 mg folic acid and 25 mg vitamin B6.  
   
   
       27 . The method of  claim 23  wherein the formulation includes approximately 1 mg B12 and 2.0 mg folic acid and 25 mg vitamin B6.  
   
   
       28 . The method of  claim 23  wherein the formulation includes approximately 1 mg B12 and 2.5 mg folic acid and 25 mg vitamin B6.  
   
   
       29 . The method of  claim 23  wherein said vascular disease is cardiovascular disease.  
   
   
       30 . The method of  claim 23  wherein said vascular disease is stroke.  
   
   
       31 . The method of  claim 23  wherein said vascular disease is peripheral vascular disease.  
   
   
       32 . The method of  claim 23  wherein said vascular disease is associated with renal disease.

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