Novel human cell surface protein with immunoglobulin folds, BGS-19

Abstract

The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

1 - 20 . (canceled)  
     
     
         21 . An isolated polypeptide comprising a polypeptide sequence selected from the group consisting of: 
 (a) an isolated polypeptide comprising amino acids 1 to 385 of SEQ ID NO:2;    (b) an isolated polypeptide comprising amino acids 2 to 385 of SEQ ID NO:2;    (c) an isolated polypeptide comprising amino acids 16 to 385 of SEQ ID NO:2    (d) an isolated polypeptide comprising the polypeptide sequence encoded by nucleotides 140 to 1294 of SEQ ID NO:1;    (e) an isolated polypeptide comprising the polypeptide sequence encoded by nucleotides 143 to 1294 of SEQ ID NO:1; and    (f) an isolated polypeptide comprising the polypeptide sequence encoded by nucleotides 185 to 1294 of SEQ ID NO:1.    
     
     
         22 . The isolated polypeptide of  claim 21 , wherein said polypeptide is (a).  
     
     
         23 . The isolated polypeptide of  claim 21 , wherein said polypeptide is (b).  
     
     
         24 . The isolated polypeptide of  claim 21 , wherein said polypeptide is (c).  
     
     
         25 . The isolated polypeptide of  claim 21 , wherein said polypeptide is (d).  
     
     
         26 . The isolated polypeptide of  claim 21 , wherein said polypeptide is (e).  
     
     
         27 . The isolated polypeptide of  claim 21 , wherein said polypeptide is (f).  
     
     
         28 . An isolated polypeptide produced by a method comprising: 
 (a) culturing an isolated recombinant host cell comprising a vector that comprises the coding region encoding the polypeptide of  claim 21  under conditions such that the polypeptide of  claim 21  is expressed; and    (b) recovering said polypeptide.    
     
     
         29 . The isolated polypeptide of  claim 21  further comprising a heterologous polypeptide sequence.  
     
     
         30 . The isolated polypeptide of claim  40  wherein said heterologous polypeptide is the Fc domain of immunoglobulin.  
     
     
         31 . An isolated polypeptide comprising the polypeptide encoded by the BGS-19 cDNA clone contained in ATCC Deposit No. PTA-3949.