Latent reactive blood compatible agents

Abstract

A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

1 - 56 . (canceled)  
   
   
       57 . A passivating biomaterial comprising a surface prepared by (a) providing a surface derivatized with a nucleophilic species, (b) reacting the surface with a reactive molecule under conditions suitable to react the reactive molecule with the nucleophilic species in order to form a bifunctional aliphatic acid attached to the surface by a covalent linkage.  
   
   
       58 . A biomaterial according to  claim 57  wherein the biomaterial is selected from the group consisting of polyolefins, polystyrenes, poly(methyl)methacrylates, polyacrylonitriles, poly(vinylacetates), poly (vinyl alcohols), chlorine-containing polymers such as poly(vinyl)chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, phenolics, amino-epoxy resins, polyesters, silicones, cellulose-based plastics, and rubber-like plastics.  
   
   
       59 . A passivated biomaterial surface, comprising a biomaterial surface having covalently attached thereto a reagent according to  claim 57 , the surface being positioned in vivo under conditions suitable to permit albumin molecules to be attracted and bound thereto in order to passivate the surface.  
   
   
       60 . A medical article fabricated from a passivating biomaterial according to  claim 59 .  
   
   
       61 . A medical article according to  claim 60 , wherein the article comprises a blood-contacting medical device for in vivo application.  
   
   
       62 . A passivated biomaterial surface comprising the surface of  claim 59  having a proteinaceous material bound thereto.