Preemptive Prophylaxis of Migraine

Abstract

A method of preventing the headache phase of migraine in a human comprises administration of a 5HT 1 receptor agonist or administration of an over-the-counter or nonprescription drug to said human exhibiting prodrome symptoms of migraine. Suitably, the method comprises administration of a migraine headache phase-preventing effective amount of the 5HT 1 or over-the-counter or nonprescription drug. There is disclosed a preemptive prophylaxis migraine method using the following cognitive tests: Simple Reaction Time; Running Memory Continuous Performance Task; Matching to Sample; Mathematical Processing Task; and interpreting the results as a percent of baseline indicator of need for prophylaxis.

1 . A preemptive prophylaxis migraine method for preventing the headache phase of a primary migraine disorder, including the steps of: 
 performing cognitive tests to determine prodromal symptoms of migraine; and    administering a non-narcotic analgesic as an anti-migraine medication.    
   
   
       2 . The preemptive prophylaxis migraine method as set forth in  claim 1 , wherein said non-narcotic analgesic is selected from the group consisting of acetylsalicylic acid (aspirin); nonsteroidal anti-inflammatory drugs (NSAIDs); and a combination of 4′-hydroxyacetanilide (acetaminophen), acetylsalicylic acid, and caffeine.  
   
   
       3 . The preemptive prophylaxis migraine method as set forth in  claim 2 , wherein said nonsteroidal anti-inflammatory drugs include COX-2 inhibitors.  
   
   
       4 . The preemptive prophylaxis migraine method as set forth in  claim 3 , wherein said COX-2 inhibitors include celecoxib and rofecoxib.  
   
   
       5 . A preemptive prophylaxis migraine method as set forth in  claim 2 , wherein said nonsteroidal anti-inflammatory drugs include acetominophen, ibuprofen, naproxen, and indomethacin.