External preparation for athlete's foot treatment

Abstract

External preparations for athlete's foot treatment capable of enhancing patient's compliance and capable of reducing the symptom of rube faction, comprising an anti- trichophton drug mixed with at least one compound selected from among 1-menthol, menthol analogue compounds and bactericidal compounds.

1 . An external preparation for athlete's foot treatment, comprising an anti- trichophyton  drug mixed with at least one compound selected from l-menthol, menthol analogue compounds and bactericidal compounds.  
   
   
       2 . The external preparation for athlete's foot treatment according to  claim 1 , wherein the anti- trichophton  drug and at least one compound selected from l-menthol, menthol analogue compounds and bactericidal compounds are blended in 0.1-10% by mass and 0.5-5% by mass respectively.  
   
   
       3 . The external preparation for athlete's foot treatment according to  claim 1 , wherein the menthol analogue compound is 3-1-menthoxypropane-1,2-diol.  
   
   
       4 . The external preparation for athlete's foot treatment according to  claim 1 , wherein the bactericidal compound is isopropylmethylphenol.  
   
   
       5 . The external preparation for athlete's foot treatment according to  claim 1 , wherein the anti- trichophton  drug is selected from benzylamine type, allylamine type, thiocarbamic acid type and imidazole type antifungal agents.  
   
   
       6 . The external preparation for athlete's foot treatment according to  claim 1 , wherein the anti- trichophton  drug is one kind selected from butenafine hydrochloride, terbinafine hydrochloride, tolnaftate, bifonazole, ketoconazole, neticonazole hydrochloride and lanoconazole.  
   
   
       7 . The external preparation for athlete's foot treatment according to  claim 1 , wherein the anti- trichophton  drug and l-menthol are blended.  
   
   
       8 . The external preparation for athlete's foot treatment according to  claim 1  comprising the anti- trichophton  drug, l-menthol and the bactericidal compound, wherein the anti- trichophton  drug is butenafine hydrochloride, the bactericidal compound is isopropylmethylphenol, and the butenafine hydrochloride l-menthol and isopropylmethylphenol are blended.  
   
   
       9 . The external preparation for athlete's foot treatment according to  claim 1 , further comprising at least one kind of a local anesthetic, an antihistamine and an anti-inflammatory drug.  
   
   
       10 . The external preparation for athlete's foot treatment according to  claim 9 , wherein the local anesthetic is dibucaine hydrochloride, or lidocaine or its salt.  
   
   
       11 . The external preparation for athlete's foot treatment according to  claim 9 , wherein the antihistamine is chlorpheniramine maleate, or diphenhydramine or its salt.  
   
   
       12 . The external preparation for athlete's foot treatment according to  claim 9 , wherein the anti-inflammatory drug is glycyrrhetinic acid or its salt, or allantoin.  
   
   
       13 . The external preparation for athlete's foot treatment according to  claim 9  comprising the anti- trichophton  drug, l-menthol, local anesthetic, antihistamine and the anti-inflammatory drug, wherein the anti- trichophton  drug is butenafine hydrochloride, the local anesthetic is dibucaine hydrochloride, the antihistamine is chlorpheniramine maleate, and the anti-inflammatory drug is glycyrrhetinic acid, and the butenafine hydrochloride, l-menthol, dibucaine hydrochloride, chlorpheniramine maleate and glycyrrhetinic acid are blended.