Latent reactive blood compatible agents

Abstract

A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

1 - 44 . (canceled)  
   
   
       45 . A passivating biomaterial comprising a biomaterial surface having covalently attached thereto a reagent-comprising a latent reactive group and a bifunctional aliphatic group, both groups being covalently attached to a spacer in a manner that permits the latent reactive group to be activated in order to attach the reagent to the surface, and that permits the aliphatic acid of the attached reagent to attract and bind a proteinaceous moiety in order to passivate the surface.  
   
   
       46 . A biomaterial according to  claim 45  wherein the biomaterial is selected from the group consisting of polyolefins, polystyrenes, poly(methyl)methacrylates, polyacrylonitriles, poly(vinylacetates), poly(vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, phenolics, amino-epoxy resins, polyesters, silicones, cellulose-based plastics, and rubber-like plastics.  
   
   
       47 . A biomaterial according to  claim 45 , the surface being positioned in vivo under conditions suitable to permit albumin molecules to be attracted and bound thereto in order to passivate the surface.  
   
   
       48 . A medical article fabricated from a passivating biomaterial according to  claim 45 .  
   
   
       49 . A medical article according to  claim 48 , wherein the article comprises a blood-contacting medical device for in vivo application.  
   
   
       50 . A passivated biomaterial surface comprising the surface of  claim 47  having a proteinaceous material bound thereto.  
   
   
       51 - 62 . (canceled)