Integrated biosensor and simulation system for diagnosis and therapy

Abstract

BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.

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         21 . Sensor apparatus comprising: 
 a multi-functional array coupled programmably to a peptide or protein sensor, an antibody sensor, a carbohydrate sensor, and a cell sensor.    
     
     
         22 . The apparatus of  claim 21  wherein: 
 the sensor array comprises a reconfigurable hardware switch logically interconnecting a plurality of biosensors to a networked controller.    
     
     
         23 . The apparatus of  claim 21  further comprising: 
 a positioning chip, coupled to one or more of the array sensors.    
     
     
         24 . The apparatus of  claim 23  wherein: 
 the positioning chip comprises a patch clamp.    
     
     
         25 . The apparatus of  claim 21  wherein: 
 the peptide or protein sensor comprises an electrophoresis tag or micro-assay, or protein chip.    
     
     
         26 . The apparatus of  claim 21  wherein: 
 the antibody sensor comprises a phagotope biochip.    
     
     
         27 . The apparatus of  claim 21  wherein: 
 the sensor array couples further to a vector or virus vector sensor comprising a micro-array or assay with known sequenced virus attached, or a micro-array or assay that detects homologs.    
     
     
         28 . The apparatus of  claim 21  wherein: 
 the carbohydrate sensor comprises a glycochip, or a whole blood glucose monitoring system.    
     
     
         29 . The apparatus of  claim 21  wherein: 
 the cell sensor comprises a bionic chip for cell-growth.    
     
     
         30 . The apparatus of  claim 21  further comprising: 
 a therapeutic unit comprising a pill comprising a micro-pump, a polymer scaffold comprising hydrogel, or an implantable bio-MEMs chip comprising a medication reservoir, such unit being coupled to at least one sensor.    
     
     
         31 . The apparatus of  claim 21  wherein: 
 the sensor array couples further to a DNA sensor comprising a micro-array or assay.    
     
     
         32 . The apparatus of  claim 31  further comprising: 
 a controller comprising a systems-biology platform that determines automatedly when the DNA sensor detects a genomic mutation indicating compromised ability to produce thiopurine S-methyltransferase enzyme.    
     
     
         33 . Sensor apparatus comprising: 
 a multi-functional array coupled programmably to a peptide or protein sensor, an antibody sensor, a carbohydrate sensor, or a cell sensor;    a positioning chip, coupled to one or more of the array sensors;    a therapeutic unit comprising a pill comprising a micro-pump, a polymer scaffold comprising hydrogel, or an implantable bio-MEMs chip comprising a medication reservoir; and    a controller that controls the therapeutic unit or the sensor array.    
     
     
         34 . Sensor apparatus comprising: 
 a multi-functional array coupled programmably to a peptide or protein sensor, an antibody sensor, a carbohydrate sensor, or a cell sensor; 
 wherein the peptide or protein sensor comprises an electrophoresis tag or micro-assay, or protein chip; the antibody sensor comprises a phagotope biochip; the carbohydrate sensor comprises a glycochip, or a whole blood glucose monitoring system; and the cell sensor comprises a bionic chip for cell-growth.  
   
     
     
         35 . The apparatus of  claim 34  wherein: 
 the sensor array couples further to a vector or virus vector sensor comprising a micro-array or assay with known sequenced virus attached, or a micro-array or assay that detects homologs; and to a DNA sensor comprising a micro-array or assay.