Delivery system for topical medications

Abstract

The present invention is a delivery system comprising a pad and a liquid composition, comprising an insoluble dermatologically active ingredient with a viscosity that permits substantially uniform absorption of the composition onto the pad, and the pad is in then packaged in a sealed container.

1 - 18 . (canceled)  
   
   
       19 . A drug delivery system comprising 
 a non-woven pad;    a liquid composition, wherein the composition comprises benzoyl peroxide, starch, carbomer, disodium EDTA, water, glycerin, sodium hydroxide, zinc lactate, glycolic acid, C12-C15 alkyl benzoate, cetearyl alcohol, dimethicone, glyceryl stearate and PEG 100 stearate, steareth 2, steareth 20, and polysorbate 20;    a sealed container, wherein the container comprises a material comprised of metal substantially coated with one or more plastics on at least one surface, and one sheet of the material is heat sealed to a second sheet of the material, and the heat sealed materials contain the pad and the composition without leaking; and    wherein the composition has a viscosity which is low enough for the composition to substantially uniformly absorb onto the pad via capillary action, and high enough to be substantially retained on the pad, not the container.    
   
   
       20 . (canceled)  
   
   
       21 . The system of  claim 19  wherein the viscosity is effective to substantially uniformly deliver the composition to skin when the pad is wiped on the skin.  
   
   
       22 . The system of  claim 19  wherein the benzoyl peroxide comprises particles of up to about 300 microns.  
   
   
       23 . The system of  claim 19  wherein the benzoyl peroxide comprises particles of less than about 50 microns.  
   
   
       24 . The system of  claim 19  wherein the benzoyl peroxide comprises particles of about 10 to about 150 microns.  
   
   
       25 . The system of  claim 19  wherein the composition is an oil-in-water emulsion.  
   
   
       26 . The system of  claim 19  wherein the composition is a water-in-oil emulsion.  
   
   
       27 . The system of  claim 19  wherein the composition has a viscosity of about 500 to about 9000 cps measured on a Brookfield viscometer LVT model at about 27° C. for 60 seconds and a spindle set for 30 rpm.  
   
   
       28 . The system of  claim 19  wherein the composition has a viscosity of about 2000 cps to about 3000 cps measured on a Brookfield viscometer LVT model at about 27° C. for 60 seconds and a spindle set for 30 rpm.  
   
   
       29 . The system of  claim 19  wherein the composition has a viscosity of about 500 to about 10,000 cps measured on a Brookfield viscometer RVT model with spindle #4 at 20 rpm for 60 seconds at 25° C.+−1° C.  
   
   
       30 . The system of  claim 19  wherein the composition has a viscosity of about 1900 to about 7,000 cps measured on a Brookfield viscometer RVT model with spindle #4 at 20 rpm for 60 seconds at 25° C.+−1° C.  
   
   
       31 . The system of  claim 19  wherein the composition has a viscosity of about 4500 to about 6,500 cps measured on a Brookfield viscometer RVT model with spindle #4 at 20 rpm for 60 seconds at 25° C.+−1° C.  
   
   
       32 . The system of  claim 19  wherein the pad comprises one or more woven materials.  
   
   
       33 . The system of  claim 19  wherein the pad comprises one or more non-woven materials.