Novel galactosylceramide analogues, and beta-glucocerebrosidase activator, external skin preparations and method of activating beta-glucocerebrosidase using the same

Abstract

Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R 1 and R 2 each represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms. R 3 represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.) It is provided a β-glucocerebrosidase activator which is easily available, and external skin preparations and a method of activating β-glucocerebrosidase, in which improvement in formation of horny layer transmission barrier is expected by activating β-glucocerebrosidase so that an improved effect in rough skin is also expected.

1 . Galactosylceramide analogues represented by the following formula (1) or (2).  
     
       
         
         
             
             
         
       
     
     wherein X is S, R 1  represents an alkyl group or alkenyl group each having 9 to 35 carbon atoms, and Y is O, R 2  represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms, and R 3  represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.  
   
   
       2 . An External skin preparation comprising one or more the galactosylceramide analogues represented by the following formula (1) or (2).  
     
       
         
         
             
             
         
       
     
   
   
       3 . An external skin preparation according to  claim 2 , wherein the galactosylceramide analogues represented by the formula (1) or (2) are contained in an amount of 0.005 to 5% by weight.  
   
   
       4 . An external skin preparations according to  claim 2 , wherein the galactosylceramide analogues represented by the formula (1) or (2) are contained in an amount of 0.01 to 3% by weight.  
   
   
       5 . An external skin preparation according to  claim 2 , wherein the preparation including a compound selected from the group consisting of lactic acid, sodium citrate and glycerin.