Method for treatment of solid pharmaceutical preparation prior to printing and solid pharmaceutical preparation subjected to treatment prior to printing

Abstract

The present invention provides a method for treating a solid dosage form to improve the printability and abrasion resistance of a print to be produced on a surface of the solid dosage form, which includes treating the surface of the solid dosage form with a polyethylene glycol-containing aqueous solution before printing; a production method of a solid dosage form with a printed surface, which includes printing on the surface after the aforementioned treatment; and a solid dosage form having a print improved in abrasion resistance on its surface, which can be obtained by the aforementioned production method.

1 . A treatment method for improving printability or abrasion resistance of a print to be produced on a surface of a solid dosage form, which comprises treating said surface with a polyethylene glycol-containing aqueous solution before printing.  
     
     
         2 . The method of  claim 1 , wherein polyethylene glycol has an average molecular weight of not less than about 1,000.  
     
     
         3 . The method of  claim 1 , wherein polyethylene glycol has an average molecular weight of about 3,000 to about 9,000.  
     
     
         4 . The method of  claim 1 , wherein the amount of polyethylene glycol to be added by the treatment is about 0.01% to about 1.0% in a weight ratio to the finished preparation.  
     
     
         5 . The method of  claim 1 , wherein the solid dosage form is a film-coated tablet.  
     
     
         6 . A method for producing a solid dosage form with a printed surface, which comprises treating the surface of the solid dosage form with a polyethylene glycol-containing aqueous solution and then printing on said surface.  
     
     
         7 . The method of  claim 6 , wherein polyethylene glycol has an average molecular weight of not less than about 1,000.  
     
     
         8 . The method of  claim 6 , wherein polyethylene glycol has an average molecular weight of about 3,000 to about 9,000.  
     
     
         9 . The method of  claim 6 , wherein the amount of polyethylene glycol to be added by the treatment is about 0.01% to about 1.0% in a weight ratio to the finished preparation.  
     
     
         10 . The method of  claim 6 , wherein the solid dosage form is a film-coated tablet.  
     
     
         11 . A solid dosage form treated by the method of  claim 1 .  
     
     
         12 . A solid dosage form with a printed surface, which can be obtained by the method of  claim 6 .  
     
     
         13 . A solid dosage form which has a coating film comprising polyethylene glycol but free of bees wax and carnauba wax on its surface, and is printed on the surface of the coating film.  
     
     
         14 . A solid dosage form treated by the method of  claim 2 .  
     
     
         15 . A solid dosage form treated by the method of  claim 3 .  
     
     
         16 . A solid dosage form treated by the method of  claim 4 .  
     
     
         17 . A solid dosage form treated by the method of  claim 5 .  
     
     
         18 . A solid dosage form with a printed surface, which can be obtained by the method of  claim 7 .  
     
     
         19 . A solid dosage form with a printed surface, which can be obtained by the method of  claim 8 .  
     
     
         20 . A solid dosage form with a printed surface, which can be obtained by the method of  claim 9 .  
     
     
         21 . A solid dosage form with a printed surface, which can be obtained by the method of  claim 10.