Stereoisomers of fatty acid analogs for diagnostic imaging

Abstract

The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention.

1 . A method of imaging cardiovascular tissue in a mammal comprising: 
 (a) administering to a mammal an imaging agent comprising a radionuclide in spatial proximity to an isomer of a fatty acid analog that includes a cyclic moiety;    (b) detecting the spatial distribution of the imaging agent in the mammal.    
     
     
         2 . The method of  claim 1  in which the cyclic moiety is a phenyl ring and the isomer is a stereoisomer.  
     
     
         3 . The method of  claim 1  in which the cyclic moiety is an aliphatic ring and the isomer is a cis or trans isomer.  
     
     
         4 . The method of  claim 3  in which the cyclic moiety is a cyclopropyl ring.  
     
     
         5 . The method of  claim 3  in which the cyclic moiety is a cyclobutyl ring.  
     
     
         6 . The method of  claim 3  in which the cyclic moiety is an oxiranyl ring.  
     
     
         7 . The method of  claim 3  in which the cyclic moiety is an thioranyl ring.  
     
     
         8 . The method of  claim 3  in which the cyclic moiety is an aziridinyl ring.  
     
     
         9 . The method of  claim 1  in which the cyclic moiety is integral to the fatty acid chain.  
     
     
         10 . The method of  claim 1  in which the cyclic moiety is pendent from the fatty acid chain.  
     
     
         11 . The method of  claim 1  in which the radionuclide is  11 C,  18 F,  62 Cu,  68 Ga,  99m  Tc,  111 In,  123 I, or  131 I.