Methods of treating cancer using IL-21

Abstract

Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

1 . A method of tumor vaccination comprising administering to a subject in need thereof an IL-21 polypeptide comprising residues 32 (Gln) to 162 (Ser) of SEQ ID NO:2 in combination with a tumor antigen expressed from injected DNA from cancers selected from the group consisting of Non-Hodgkins lymphoma, renal cell carcinoma, breast cancer, prostate cancer, ovarian cancer, and colon cancer.  
     
     
         2 . The method according to  claim 1 , wherein the polypeptide has been shown to not cause proliferation of isolated cancer cells prior to administration to the subject.  
     
     
         3 . The method of  claim 1 , wherein there is a tumor response.  
     
     
         4 . The method of  claim 3 , wherein a tumor response is measured as complete response, partial response or reduction in time to progression.  
     
     
         5 . The method of  claim 1 , wherein tumor antigen expressed from injected DNA is from renal cell carcinoma.