US2007129299A1PendingUtilityA1

Compositions and methods for enhanced mucosal delivery of pyy peptide

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Assignee: NASTECH PHARM COPriority: Dec 17, 2002Filed: Aug 25, 2006Published: Jun 7, 2007
Est. expiryDec 17, 2022(expired)· nominal 20-yr term from priority
Inventors:Steven C. QuayGordon BrandtMary KleppeConor Macevilly
A61P 43/00A61P 3/10A61K 47/26A61K 38/22A61K 31/724A61K 45/06A61K 38/2271A61K 47/24A61P 25/28A61P 35/00A61K 47/40A61K 9/0043A61K 9/08A61P 3/04
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Claims

Abstract

Pharmaceutical compositions are described comprising PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol.

Claims

exact text as granted — not AI-modified
1 . A peptide YY (PYY) composition comprised of PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.  
     
     
         2 . The PYY composition of  claim 1  wherein the solubilizing agent is selected from the group consisting of a cyclodextrin, hydroxypropyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin and methyl-β-cyclodextrin.  
     
     
         3 . The PYY composition of  claim 2  wherein the solubilizing agent is a methyl-β-cyclodextrin.  
     
     
         4 . The PYY composition of  claim 1  wherein the lipid is a phospholipid.  
     
     
         5 . The PYY composition of  claim 4  wherein the phospholipid is a phosphatidylcholine.  
     
     
         6 . The PYY composition of  claim 5  wherein the phosphatidylcholine is L-α-phosphatidylcholine didecanoyl (DDPC).  
     
     
         7 . The PYY composition of  claim 1  wherein the polyol is sorbitol.  
     
     
         8 . The PYY composition of  claim 1  wherein the composition is further comprised of a chelating agent.  
     
     
         9 . The PYY composition of  claim 8  wherein the chelating agent is ethylene diamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA).  
     
     
         10 . The PYY composition of  claim 9  wherein the chelating agent is EDTA.  
     
     
         11 . The PYY composition of  claim 1  wherein the composition is an aqueous PYY composition further comprised of water.  
     
     
         12 . The PYY composition of  claim 11  wherein the aqueous PYY composition has a pH of about of about 3 to about 6.  
     
     
         13 . The PYY composition of  claim 12  wherein the pH of the aqueous PYY composition is 5.0±0.5.  
     
     
         14 . A PYY composition comprised of a solubilizing agent, a phosphatidylcholine, a polyol, and PYY(3-36) (SEQ ID NO: 2).  
     
     
         15 . The PYY composition of  claim 14  wherein the polyol is selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.  
     
     
         16 . The PYY composition of  claim 15  wherein the polyol is sorbitol.  
     
     
         17 . The PYY composition of  claim 14  wherein the composition further comprises a chelating agent.  
     
     
         18 . The PYY composition of  claim 17  wherein the chelating agent is ethylene diamine tetraacetic acid (EDTA) or ethylene glycol tetraacetic acid (EGTA).  
     
     
         19 . The PYY composition of  claim 18  wherein the chelating agent is EDTA.  
     
     
         20 . The PYY composition of  claim 14  wherein the solubilizing agent is selected from the group consisting of a cyclodextrin, hydroxypropyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin and methyl-β-cyclodextrin.  
     
     
         21 . The PYY composition of  claim 20  wherein the solubilizing agent is a methyl-β-cyclodextrin.  
     
     
         22 . The PYY composition of  claim 14  wherein the phosphatidylcholine is L-α-phosphatidylcholine didecanoyl (DDPC).  
     
     
         23 . The PYY composition of  claim 14  wherein the composition is an aqueous PYY composition further comprised of water.  
     
     
         24 . The PYY composition of  claim 23  wherein the aqueous PYY composition has a pH of about 3 to about 6.  
     
     
         25 . The PYY composition of  claim 25  wherein the pH of the aqueous PYY composition is 5.0±0.5.  
     
     
         26 . A peptide YY (PYY) composition comprised of PYY(3-36) (SEQ ID NO: 2), a polyol, EDTA, and a surfactant selected from the group consisting of Tween 20, Tween 80, cetyl alcohol, and lanolin alcohol lipid.  
     
     
         27 . The PYY composition of  claim 26 , where in polyol is selected from the group consisting of sucrose, mannitol, sorbitol, lactose, L-arabinose, D-erythrose, D-ribose, D-xylose, D-mannose, trehalose, D-galactose, lactulose, cellobiose, gentibiose, glycerin and polyethylene glycol.  
     
     
         28 . The PYY composition of  claim 26  wherein the aqueous PYY composition has a pH of about 3 to about 6.  
     
     
         29 . The PYY composition of  claim 26  wherein the pH of the aqueous PYY composition is 5.0±0.5.

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