Devices and methods for the delivery of blood clotting materials to bleeding wounds

Abstract

An apparatus for promoting the clotting of blood comprises a receptacle, at least a portion of which is defined by a mesh having openings therein, and particles of clay retained in the receptacle. In similar apparatuses, bioactive glass or chitosan is retained in the receptacle. An apparatus also comprises a receptacle defined by a mesh having openings therein, and first and second blood clotting materials enclosed in the mesh. In a method of dressing a bleeding wound, a first blood clotting material in particle form is provided and retained in a mesh structure, and a second blood clotting material is provided and incorporated into a material of the mesh structure. The mesh structure is placed on a bleeding wound such that the second blood clotting material contacts wounded tissue of the bleeding wound.

1 . An apparatus for promoting the clotting of blood, comprising: 
 a receptacle, at least a portion of said receptacle being defined by a mesh having openings therein; and    a clay in particulate form retained in said receptacle, said clay providing a blood clotting function;    wherein when treating a bleeding wound, application of said apparatus causes at least a portion of said clay to come into contact with blood through said openings.    
   
   
       2 . The apparatus for promoting the clotting of blood of  claim 1 , wherein said clay is selected from the group consisting of attapulgite, bentonite, kaolin, kaolinite, and combinations of the foregoing.  
   
   
       3 . The apparatus for promoting the clotting of blood of  claim 1 , wherein said clay is Edgar's plastic kaolin.  
   
   
       4 . The apparatus for promoting the clotting of blood of  claim 1 , wherein said mesh is flexible.  
   
   
       5 . The apparatus for promoting the clotting of blood of  claim 1 , wherein a material of said mesh defines a matrix in which clay material is captured.  
   
   
       6 . The apparatus for promoting the clotting of blood of  claim 1 , wherein a material of said mesh includes clay material.  
   
   
       7 . The apparatus for promoting the clotting of blood of  claim 1 , wherein a material of said mesh includes bioactive glass.  
   
   
       8 . The apparatus for promoting the clotting of blood of  claim 1 , wherein a material of said mesh includes chitosan.  
   
   
       9 . The apparatus for promoting the clotting of blood of  claim 1 , wherein a material of said mesh includes a material selected from the group consisting of poly-N-acetylglucosamine (derived from algae), thrombin, fibrin, microporous polymer particles, microporous polysaccharide particles, gelatin sponge, microfibrillar collagen, oxidized cellulose, zeolite, and combinations of the foregoing.  
   
   
       10 . The apparatus for promoting the clotting of blood of  claim 1 , wherein a material from which said mesh is fabricated is selected from the group consisting of polymers, metals, fiberglass, organic substances, oxidized cellulose, and cellulose-based materials.  
   
   
       11 . The apparatus for promoting the clotting of blood of  claim 1 , wherein said clay further comprises a material selected from the group consisting of antibiotics, antibacterial agents, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, bacteriostatics, compounds containing silver ions, wound healing agents, ascorbic acid, tranexamic acid, rutin, thrombin, botanical agents, and combinations of the foregoing materials.  
   
   
       12 . An apparatus for promoting the clotting of blood, comprising: 
 a receptacle, at least a portion of said receptacle being defined by a mesh having openings therein; and    a bioactive glass in particulate form retained in said receptacle, said bioactive glass providing a blood clotting function;    wherein when treating a bleeding wound, application of said apparatus causes at least a portion of said bioactive glass to come into contact with blood through said openings.    
   
   
       13 . The apparatus for promoting the clotting of blood of  claim 12 , wherein a material of said mesh includes clay material.  
   
   
       14 . The apparatus for promoting the clotting of blood of  claim 12 , wherein a material of said mesh includes bioactive glass.  
   
   
       15 . The apparatus for promoting the clotting of blood of  claim 12 , wherein a material of said mesh includes chitosan.  
   
   
       16 . The apparatus for promoting the clotting of blood of  claim 12 , wherein a material of said mesh includes a material selected from the group consisting of poly-N-acetylglucosamine (derived from algae), thrombin, fibrin, microporous polymer particles, microporous polysaccharide particles, gelatin sponge, microfibrillar collagen, oxidized cellulose, zeolite, and combinations of the foregoing.  
   
   
       17 . The apparatus for promoting the clotting of blood of  claim 12 , wherein said bioactive glass further comprises a material selected from the group consisting of antibiotics, antibacterial agents, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, bacteriostatics, compounds containing silver ions, wound healing agents, ascorbic acid, tranexamic acid, rutin, thrombin, botanical agents, and combinations of the foregoing materials.  
   
   
       18 . An apparatus for promoting the clotting of blood, comprising: 
 a receptacle, at least a portion of said receptacle being defined by a mesh having openings therein; and    chitosan in particulate form retained in said receptacle, said chitosan providing a blood clotting function;    wherein when treating a bleeding wound, application of said apparatus causes at least a portion of said chitosan to come into contact with blood through said openings.    
   
   
       19 . The apparatus for promoting the clotting of blood of  claim 18 , wherein a material of said mesh includes clay material.  
   
   
       20 . The apparatus for promoting the clotting of blood of  claim 18 , wherein a material of said mesh includes bioactive glass.  
   
   
       21 . The apparatus for promoting the clotting of blood of  claim 18 , wherein a material of said mesh includes chitosan.  
   
   
       22 . The apparatus for promoting the clotting of blood of  claim 18 , wherein a material of said mesh includes a material selected from the group consisting of poly-N-acetylglucosamine (derived from algae), thrombin, fibrin, microporous polymer particles, microporous polysaccharide particles, gelatin sponge, microfibrillar collagen, oxidized cellulose, zeolite, and combinations of the foregoing.  
   
   
       23 . The apparatus for promoting the clotting of blood of  claim 18 , wherein said chitosan further comprises a material selected from the group consisting of antibiotics, antibacterial agents, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, bacteriostatics, compounds containing silver ions, wound healing agents, ascorbic acid, tranexamic acid, rutin, thrombin, botanical agents, and combinations of the foregoing materials.  
   
   
       24 . An apparatus for promoting the clotting of blood, comprising: 
 a receptacle defined by a mesh having openings therein;    a first blood clotting material enclosed in said mesh; and    a second blood clotting material incorporated into a material of said mesh, said second blood clotting material being selected from the group consisting of clay, bioactive glass, chitosan, and combinations of the foregoing;    wherein when treating a bleeding wound, application of said apparatus causes at least a portion of said second blood clotting material to come into contact with blood.    
   
   
       25 . The apparatus for promoting the clotting of blood of  claim 24 , wherein said first blood clotting material is selected from the group consisting of zeolite, oxidized cellulose, clay, bioactive glass, chitosan, and combinations of the foregoing.  
   
   
       26 . The apparatus for promoting the clotting of blood of  claim 25 , wherein said first blood clotting material further comprises a material selected from the group consisting of antibiotics, antibacterial agents, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, bacteriostatics, compounds containing silver ions, wound healing agents, ascorbic acid, tranexamic acid, rutin, thrombin, botanical agents, and combinations of the foregoing materials.  
   
   
       27 . The apparatus of  claim 24 , wherein said first blood clotting material is in particle form.  
   
   
       28 . The apparatus of  claim 24 , further comprising a substrate on which said receptacle is mounted.  
   
   
       29 . The apparatus of  claim 28 , further comprising an adhesive disposed on said substrate to form an adhesive bandage.  
   
   
       30 . A method of dressing a bleeding wound, said method comprising the steps of: 
 providing a first blood clotting material in particle form and retained in a mesh structure;    providing a second blood clotting material incorporated into a material of said mesh structure;    placing said mesh structure on a bleeding wound such that said second blood clotting material contacts wounded tissue of said bleeding wound;    applying pressure to said mesh structure; and    removing said mesh structure from said wound.    
   
   
       31 . The method of  claim 30 , further comprising the step of holding said mesh structure on said bleeding wound using a strapping device.