Substances and agents for positively influencing collagen

Abstract

The invention relates to the use of a substance and/or substances or a composition containing said substance and/or substances, whereby said substance and/or substances inhibit(s) the formation and/or the effect of estrogen to stabilize, increase and/or restore collagen. The appropriate substances are aromatase inhibitors and/or anti-estrogens. Optionally, 5-alpha-reductase inhibitors are also used.

1 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the stabilization, the increase and/or the restoration of collagen.  
   
   
       2 . Use according to  claim 1 , characterized in that the substance is selected from the group consisting of aromatase inhibitors and anti-estrogens.  
   
   
       3 . Use according to  claim 1 , characterized in that the substance is an aromatase inhibitor.  
   
   
       4 . Use according to  claim 1 , characterized in that the substance is derived from soya glycine.  
   
   
       5 . Use according to  claim 4 , characterized in that the substance from soya glycine had been treated by oxidation.  
   
   
       6 . Use according to any of the preceding claims, characterized in that the substance is contained in the composition in an amount of 0.001 to 5 wt.-%, relative to the total amount of the composition.  
   
   
       7 . Use according to any one of the preceding claims, characterized in that the composition comprises both an aromatase inhibitor and an anti-estrogen.  
   
   
       8 . Use according to any one of the preceding claims, characterized in that an inhibition of the production and/or the effect of dihydrotestosterone is performed at the same time or in addition.  
   
   
       9 . Use according to  claim 8 , characterized in that an aromatase inhibitor is combined with a 5-alpha-reductase inhibitor.  
   
   
       10 . Use according to  claim 7 , characterized in that a substance is used which has both an inhibitory effect on aromatase and on 5-alpha-reductase.  
   
   
       11 . Use according to any one of the preceding claims, characterized in that a local application is performed.  
   
   
       12 . Use according to any one of the preceding claims, characterized in that it serves for cosmetic purposes.  
   
   
       13 . Use according to any one of the preceding claims, characterized in that it serves for the stabilization, the increase and/or the restoration of collagen in one or more of the following body regions: skin, ligaments, fasciae, tendons, cartilages, bones, dentine and the vessel walls of arteries, veins and urinary passageways.  
   
   
       14 . Use according to any one of the preceding claims, characterized in that the substance is contained in a pharmaceutical formulation which is suitable for the topical application, for injection, for inhalation or for transdermal therapy.  
   
   
       15 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the prophylaxis of myocardial infarction and brain infarction.  
   
   
       16 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the prophylaxis or therapy of osteoporosis.  
   
   
       17 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the prophylaxis or therapy of arteriosclerosis.  
   
   
       18 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the prophylaxis or therapy of urinary incontinence.  
   
   
       19 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the prophylaxis or therapy in the case of excessive production of glucocorticoids in the body, or as a therapy accompanying the therapeutic use of glucocorticoids for the decrease of side effects which are associated with glucocorticoids.  
   
   
       20 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the decrease of hair growth in women.  
   
   
       21 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the cosmetic treatment of wrinkles and/or strias of the skin as well as atony of the upper skin.  
   
   
       22 . Use of a substance which inhibits the production and/or the effect of estrogens, or a composition containing said substance, for the amelioration of sun exposure to the skin.  
   
   
       23 . Use according to any one of  claims 15  to  22 , characterized in that a substance or a composition as defined in any one of  claims 2  to  10  is used.  
   
   
       24 . Cosmetic composition for topical application, characterized in that the composition comprises one or more substance(s) such that the production and/or the effect of estrogens and, at the same time, the production and/or the effect of dihydrotestosterone is inhibited.  
   
   
       25 . Cosmetic composition according to  claim 24 , characterized in that an aromatase inhibitor is combined with a 5-alpha-reductase inhibitor.  
   
   
       26 . Cosmetic composition according to  claim 24 , characterized in that the composition comprises a substance which has both an inhibitory effect on aromatase and on 5-alpha-reductase.