Denture fixative composition

Abstract

A denture fixative composition containing lower alkyl vinyl ether-maleic anhydride copolymers, water-insoluble and water-swelling polymers, and at least one additional adhesive material which can be used as a denture fixative paste, liquid, powder, aerosol, dissolving tablet, liner or adhesive-like strip.

1 . A denture fixative composition consisting essentially of: 
 a. a lower alkyl vinyl ether-maleic anhydride copolymer or a derivative thereof;    b. at least one water-insoluble and water-swelling polymer; and    c. at least one additional adhesive material selected from the group consisting of natural gums, synthetic polymeric gums, karaya gum, guar gum, gelatin, algin, sodium alginate, tragacanth, chitosan, polyethylene glycol, acrylamide polymers, carbopol, polyvinyl alcohol, polyvinylpyrrolidone, cellulose derivatives and mixtures thereof.    
     
     
         2 . The denture fixative composition of  claim 1  wherein the water-insoluble and water-swelling polymer is present at a level from about 1 to 60% by weight of the denture fixative composition.  
     
     
         3 . The denture fixative composition of  claim 1  wherein the additional adhesive material is a cellulose derivative selected from the group consisting of methylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyl propylmethylcellulose, carboxymethylcellulose, and mixtures thereof.  
     
     
         4 . The denture fixative composition of  claim 2  wherein the additional adhesive material is sodium carboxymethylcellulose.  
     
     
         5 . The denture fixative composition of  claim 1  where in the additional adhesive material is present at a level of from about 1 to about 35% by weight of the denture fixative composition.  
     
     
         6 . The denture fixative composition of  claim 1  wherein the water-insoluble and water-swelling polymer is water-insoluble at ambient temperature.  
     
     
         7 . The denture fixative composition of  claim 6  wherein the water-insoluble and water-swelling polymer is selected from the group consisting of low-substituted hydroxypropyl ether of cellulose, croscarmellose sodium, carboxymethylcellulose calcium, agar and mixtures thereof.  
     
     
         8 . The denture fixative composition of  claim 7  wherein the water-insoluble and water-swelling polymer has a particle size under about 200 microns.  
     
     
         9 . The denture fixative composition of  claim 7  wherein the water-insoluble and water-swelling polymer is a low-substituted hydroxypropyl ether of cellulose or a derivative thereof.  
     
     
         10 . The denture fixative composition of  claim 7  wherein the water-insoluble and water-swelling polymer is a low-substituted hydroxypropyl ether of cellulose having a hydroxypropyl content of about 5.0-16.0%.  
     
     
         11 . The denture fixative composition of  claim 7  wherein the water-insoluble and water-swelling polymer is a low-substituted hydroxypropyl ether of cellulose having a hydroxypropyl content of about 10.0-12.9%.  
     
     
         12 . The denture fixative composition of  claim 7  wherein the water-insoluble and water-swelling polymer is agar.  
     
     
         13 . The denture fixative composition of  claim 12  wherein the water-insoluble and water-swelling polymer is agar having an average molecular weight from 700,000 to 800,000.  
     
     
         14 . The denture fixative composition of  claim 1  wherein the water-insoluble and water-swelling polymer is present at a level of from about 1 to about 30% by weight of the denture fixative composition.  
     
     
         15 . The denture fixative composition of  claim 1  wherein the lower alkyl vinyl ether-maleic salt copolymer comprises a cationic ion selected from the group consisting of monovalent, bivalent, trivalent cations and mixtures thereof.  
     
     
         16 . The denture fixative composition of  claim 15  wherein the cationic ion is selected from the group consisting of calcium, sodium, and mixtures thereof.  
     
     
         17 . The denture fixative composition of  claim 1  wherein the lower alkyl vinyl ether-maleic anhydride copolymer or a derivative thereof is present at a level of from about 10 to about 55% by weight.  
     
     
         18 . The denture fixative composition of  claim 1  further including an emollient at a level of from about 10 to about 50% by weight of the denture fixative composition.  
     
     
         19 . The denture fixative composition of  claim 18  wherein the emollient is selected from the group consisting of petroleum jelly, mineral oil, other types of hydrocarbons and mixtures thereof.  
     
     
         20 . The denture fixative composition of  claim 1  further including silicon dioxide at a level of from about 0.1 to about 9% by weight of the denture fixative composition.  
     
     
         21 . The denture fixative composition of  claim 1  further including one or more components selected from the group consisting of flavorants, colorants, preservatives, and mixtures thereof.  
     
     
         22 . The denture fixative composition of  claim 1  further including a therapeutic component selected from the group consisting of medically acceptable anti-bacterial agents, anti-fungal agents, anti-inflammatory agents and mixtures thereof.