Bipolar trans carotenoid salts and their uses

Abstract

The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

1 .- 13 . (canceled)  
   
   
       14 . A method of increasing the diffusivity of oxygen in a mammal comprising administering to a mammal a therapeutically effective amount of a compound having the formula: 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       15 . A method as in  claim 14  wherein said administration is by inhalation.  
   
   
       16 . A method of treating respiratory disease comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula: 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       17 . A method of treating emphysema comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       18 . A method of treating hemorrhagic shock comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       19 . A method of treating cardiovascular disease comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       20 . A method of treating atherosclerosis comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       21 . A method of treating asthma comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       22 . A method of treating spinal cord injuries comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       23 . A method of treating cerebral edema comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       24 . A method of treating papillomas comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       25 . A method of treating hypoxia comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       26 .- 39 . (canceled)  
   
   
       40 . A method of increasing the diffusivity of oxygen in a mammal comprising administering to a mammal by inhalation a therapeutically effective amount of TSC.  
   
   
       41 .- 48 . (canceled)  
   
   
       49 . A method of treating ischemia comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula: 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       50 . A method of treating traumatic brain injury comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton,  
   wherein said compound is not TSC.    
   
   
       51 . A method of enhancing performance of a mammal comprising administering to said mammal a therapeutically effective amount of a compound having the formula: 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton.  
   
   
   
       52 . A method of treating complications of diabetes comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton.  
   
   
   
       53 . A method of treating Alzheimer's disease comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having the formula 
       YZ-TCRO-ZY where: 
 Y=a cation  
 Z=a polar group which is associated with the cation, and  
 TCRO=trans carotenoid skeleton.  
   
   
   
       54 .- 59 . (canceled)