Complex Mixtures Exhibiting Selective Inhibition of Cyclooxygenase-2

Abstract

A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammatory response in animals. The formulation comprises an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.

1 . A composition comprising a pharmaceutical grade extract of hops comprising an effective amount of tetrahydroisohumulone and an effective amount of at least one component selected from the group consisting of essential oils, fats and waxes, wherein said pharmaceutical grade extract provides about 0.5 to 100 mg per kg of body weight per day of tetrahydroisohumulone.  
   
   
       2 . A composition comprising a pharmaceutical grade extract of hops comprising an effective amount of tetrahydroisohumulone and an effective amount of at least one component selected from the group consisting of essential oils, fats and waxes, wherein said pharmaceutical grade extract provides 10 to 95 weight % of tetrahydroisohumulone of the composition.  
   
   
       3 . The composition according to claims  1  or  2 , further comprising a pharmaceutical acceptable carrier selected from the group consisting of coatings, isotonic and absorption delaying agents, binders and adhesives, lubricants, disintegrants, coloring agents, flavoring agents, sweetening agents, absorbants, detergents, and emulsifying agents.  
   
   
       4 . The composition according to claims  1  or  2 , further comprising a member selected from the group consisting of antioxidants, vitamins and minerals.  
   
   
       5 . The composition according to claims  1  or  2 , further comprising a member selected from the group consisting of proteins, fats, carbohydrates, glucosamine, chondroitin sulfate and amino sugars.  
   
   
       6 . A dosage form of a pharmaceutical grade extract of hops comprising an effective amount of tetrahydroisohumulone and an effective amount of at least one component selected from the group consisting of essential oils, fats, and waxes, wherein said pharmaceutical grade extract provides about 0.5 to 100 mg per kg of body weight per day of tetrahydroisohumulone.  
   
   
       7 . A dosage form of a pharmaceutical grade extract of hops comprising an effective amount of tetrahydroisohumulone and an effective amount of at least one component selected from the group consisting of essential oils, fats, and waxes, wherein said pharmaceutical grade extract provides 10 to 95 weight % of tetrahydroisohumulone of the composition.  
   
   
       8 . The dosage form according to claims  6  or  7 , wherein said dosage form is a capsule, powder, tablet, injectable suspension, spray solution, spray suspension, or lotion.  
   
   
       9 . The dosage form according to claims  6  or  7 , further comprising a pharmaceutical acceptable carrier selected from the group consisting of coatings, isotonic and absorption delaying agents, binders and adhesives, lubricants, disintegrants, coloring agents, flavoring agents, sweetening agents, absorbants, detergents, and emulsifying agents.