Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease

Abstract

Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids, IAP fragments, and antibodies which specifically bind IAP polypeptides.

1 . An antisense nucleic acid which inhibits the biological activity of an inhibitor of apoptosis (IAP) in vivo, wherein the nucleic acid is complementary to a mammalian IAP nucleic acid sequence encoding an IAP polypeptide selected from the group consisting of: human X-linked IAP (XIAP) (SEQ ID NO:3), human IAP-1 (HIAP-1) (SEQ ID NO:5), human IAP-2 (HIAP-2) (SEQ ID NO:7), murine XIAP (SEQ ID NO:9), murine XIAP-1 (SEQ ID NO:11) and murine XIAP-2 (SEQ ID NO:13).  
     
     
         2 . The antisense nucleic acid, according to  claim 1 , in which the inhibitor of apoptosis (IAP) biological activity is inhibition of apoptosis.  
     
     
         3 . The antisense nucleic acid, according to  claim 1 , in which the inhibitor of apoptosis (IAP) biological activity is inhibited by at least 25%.  
     
     
         4 . The antisense nucleic acid, according to  claim 1 , in which the inhibitor of apoptosis (IAP) is human IAP-1 (HIAP-1).  
     
     
         5 . The antisense nucleic acid, according to  claim 1 , in which the inhibitor of apoptosis (IAP) is human IAP-2 (HIAP-2).  
     
     
         6 . The antisense nucleic acid, according to  claim 1 , in which the inhibitor of apoptosis (IAP) is human X-linked IAP (XIAP).  
     
     
         7 . The antisense nucleic acid, according to  claim 1 , in which the antisense nucleic acid is murine.  
     
     
         8 . The antisense nucleic acid, according to  claim 1 , in which the antisense nucleic acid is human.