Methods for identification, assessment, prevention, and therapy of cancer

Abstract

The present invention relates to the newly identified cancer therapeutic targets and biomarkers. These targets/biomarkers are overexpressed in carcinomas generally, and more specifically to adenocarcinoma and squamous cell carcinoma. The invention provides methods of diagnosis, characterization, and therapy of carcinoma based on the degree of overexpression of the targets/biomarkers.

1 .- 20 . (canceled)  
     
     
         21 . A method of assessing whether a patient is afflicted with a carcinoma selected from the group consisting of colon cancer, breast cancer, lung cancer, ovarian cancer, cervical cancer and prostate cancer, the method comprising a) determining the amount of a polypeptide marker in a patient sample, wherein the marker is selected from Table 1; b) determining the normal amount of the polypeptide marker in a control non-cancerous sample; and c) comparing the amounts of the polypeptide marker between the patient sample and the control non cancerous sample, wherein a significant increase in the amount of the polypeptide marker in the patient sample from the normal level is an indication that the patient is afflicted with the carcinoma.  
     
     
         22 . The method of  claim 21 , wherein the carcinoma is ovarian cancer.  
     
     
         23 . The method of  claim 21  wherein the amount of the polypeptide marker is determined by binding the polypeptide marker with an antibody.  
     
     
         24 . The method of  claim 23  wherein the antibody is derived from the full-length polypeptide marker or fragment thereof.  
       
         
           
                 
                 
                 
                 
               
                   TABLE 1 
                 
                     
                 
                     
                 
                     
                   SEQ ID NO 
                   SEQ ID NO 
                     
                 
                     
                   (nucleotide 
                   (amino acid 
                 
                   Gene Name 
                   sequence) 
                   sequence) 
                   CDS 
                 
                     
                 
                   IRTKS: Insulin 
                   1 
                   2 
                   217 . . . 1752 
                 
                   receptor tyrosine 
                 
                   kinase substrate 
                 
                   Solt: 
                   3 
                   4 
                   265 . . . 1074 
                 
                   SoxLZ/Sox6-binding 
                 
                   protein Solt 
                 
                   Shax3: Snf7 
                   5 
                   6 
                   179 . . . 880  
                 
                   homologue 
                 
                   associated 
                 
                   with Alix 3 
                 
                   WBSCR21: Williams 
                   7 
                   8 
                   63 . . . 368 
                 
                   Beuren syndrome 
                 
                   chromosome 
                 
                   region 21 
                 
                     
                 
                     
                 
             
                
                
                
                
                
                
                
               
               
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
       
         
           
                 
                 
                 
               
                   TABLE 2 
                 
                     
                 
                     
                 
                     
                   SEQ ID NO 
                   SEQ ID NO 
                 
                     
                   (nucleotide 
                   (nucleotide 
                 
                     
                   sequence) 
                   sequence) 
                 
                   Gene Name 
                   Forward Primer 
                   Reverse Primer 
                 
                     
                 
                     
                 
                 
                 
                 
               
                   IRTKS: Insulin receptor tyrosine 
                   9 
                   10 
                 
                   kinase substrate 
                 
                   Solt: SoxLZ/Sox6-binding protein Solt 
                   11 
                   12 
                 
                   Shax3: Snf7 homologue associated with 
                   13 
                   14 
                 
                   Alix 3 
                 
                   WBSCR21: Williams Beuren syndrome 
                   15 
                   16 
                 
                   chromosome region 21