Controlled Release Matrix Pharmaceutical Dosage Formulation

Abstract

The invention proves a novel compressed tablet of a pharmaceutical compound and a method of making a tablet of a pharmaceutical compound which are based on uncoated pellets containing a pharmaceutical compound that are dispersed in a matrix which comprises said pellets and a swellable polymer which is compressed into a tablet.

1 . A compressed tablet of a pharmaceutical compound which comprises uncoated pellets containing a pharmaceutical compound, said pellets being dispersed in a matrix which comprises said pellets and a swellable polymer.  
   
   
       2 . A compressed tablet of a pharmaceutical compound as defined in  claim 1  wherein the uncoated pellets contain a pharmaceutical excipient.  
   
   
       3 . A compressed tablet of a pharmaceutical compound as defined in  claim 1  wherein the pharmaceutical excipient is selected from the group consisting of microcrystalline cellulose, dicalcium phosphate, calcium sulfate, talc, silicon dioxide and calcium carbonate.  
   
   
       4 . A compressed tablet of a pharmaceutical compound as defined in  claim 1  wherein the swellable polymer is selected from the group consisting of carbomer, hydroxy propyl cellulose, hydroxypropyl methylcellulose and polyvinylpyrrolidone.  
   
   
       5 . A compressed tablet of a pharmaceutical compound as defined in  claim 2  wherein the swellable polymer is carbomer.  
   
   
       6 . A compressed tablet of a pharmaceutical compound as defined in  claim 4  wherein the swellable polymer is carbomer.  
   
   
       7 . A compressed tablet of a pharmaceutical compound which comprises uncoated pellets containing pharmaceutical compound and microcrystalline cellulose and dicalcium phosphate; said pellets being dispersed in a matrix which comprises said uncoated pellets, a carbomer and microcrystalline cellulose polymer which is compressed into a tablet.  
   
   
       8 . A compressed tablet as defined in  claim 1  where the pharmaceutical compound is ibuprofen.  
   
   
       9 . A compressed tablet as defined in  claim 1  where the pharmaceutical compound is oxybutynin chloride.  
   
   
       10 . A compressed tablet as defined in  claim 1  where the pharmaceutical compound is metoprolol succinate.  
   
   
       11 . A compressed tablet as defined in  claim 1  where the pharmaceutical compound is propranolol hydrochloride.  
   
   
       12 . A compressed tablet as defined in  claim 1  where the pharmaceutical compound is chlorpheniramine maleate.  
   
   
       13 . A method of making a tablet of a pharmaceutical compound which comprises; 
 (a) preparing uncoated pellets containing a pharmaceutical compound;    (b) dispersing said uncoated pellets in a matrix which comprises a swellable polymer; and    (c) compressing said matrix into a tablet.    
   
   
       14 . A method of making a tablet of a pharmaceutical compound as defined in  claim 13  wherein the uncoated pellets contain a pharmaceutical excipient.  
   
   
       15 . A method of making a tablet of a pharmaceutical compound as defined in  claim 13  wherein the pharmaceutical excipient is selected from the group consisting of microcrystalline cellulose, dicalcium phosphate, calcium sulfate, talc, silicon dioxide and calcium carbonate.  
   
   
       16 . A method of making a tablet of pharmaceutical compound as defined in  claim 13  wherein the swellable polymer is selected from the group consisting of carbomer, hydroxy propyl cellulose, hydroxypropyl methylcellulose and polyvinylpyrrolidone.  
   
   
       17 . A method of making a tablet of a pharmaceutical compound as defined in  claim 16  wherein the swellable polymer is carbomer.  
   
   
       18 . A method of making a tablet of a pharmaceutical compound as defined in  claim 14  wherein the swellable polymer is carbomer.  
   
   
       19 . A method of making a tablet of a pharmaceutical compound which comprises; 
 (a) preparing uncoated pellets containing a pharmaceutical compound, microcrystalline cellulose and dicalcium phosphate;    (b) dispersing said uncoated pellets in a matrix which comprises a carbomer and microcrystalline cellulose; and    (c) compressing said matrix into a tablet.