Method for stabilizing blood pressure in hemodialysis subjects

Abstract

The present invention provides a method for regulating blood pressure in a hemodialysis subject using a vasopressin receptor agonist, so as to facilitate removal of excessive extracellular fluid in the subject.

1 . A method for reducing excess extracellular fluid in a subject undergoing hemodialysis comprising administering a V-1 receptor agonist to the subject in an effective amount and thereby maintaining blood pressure during hemodialysis in order to facilitate reducing excess extracellular fluid in the subject.  
     
     
         2 . A method for stabilizing high blood pressure between hemodialysis treatments in a subject undergoing hemodialysis by reducing excess extracellular fluid by the method of  claim 1 .  
     
     
         3 . A method for inhibiting interdialytic hypertension by regulating blood pressure by the method of  claim 2 .  
     
     
         4 . A method for inhibiting intradialytic hypotension by regulating blood pressure by the method of  claim 1 .  
     
     
         5 . The method of  claim 1 , wherein the V-1 receptor agonist is arginine vasopressin.  
     
     
         6 . The method of  claim 1 , wherein the V-1 receptor agonist is lysine vasopressin.  
     
     
         7 . The method of  claim 1 , wherein the V-1 receptor agonist is terlipressin.  
     
     
         8 . The method of  claim 1 , wherein the V-1 receptor agonist is octapressin  
     
     
         9 . The method of  claim 1 , wherein the V-1 receptor agonist is omipressin  
     
     
         10 . The method of  claim 1 , wherein the V-1 receptor agonist is an organic molecule selected from the group consisting of 3-beta-(2-thienyl)-L-alanine)-8-lysine-vasopressin, N-alpha-glycyl-glycyl-glycyl-[8-lysine]-vasopressin, and 1-deamino-6-carba-[8-arginine]-vasopressin.  
     
     
         11 . The method of  claim 1 , wherein the effective amount of the V-1 receptor agonist is in a range of about 0.05 milliunits/kg/minute-2.0 milliunits/kg/hr.  
     
     
         12 . The method of  claim 1 , wherein the effective amount of the V-1 receptor agonist is about 0.3 milliunits/kg/minute.  
     
     
         13 . The method of  claim 1 , wherein the subject is a human, non-human primate, rabbit, sheep, rat, dog, cat, pig, or mouse.