Separating agent for enantiomeric isomers

Abstract

The present invention provides a separating agent for enantiomeric isomers having no large UV absorption, as represented by an aromatic group, and having high asymmetric recognizability, particularly, high asymmetric recognizability in an aqueous mobile phase, or a separating agent for enantiomeric isomers containing a polysaccharide alicyclic ester derivative free from an aromatic group as an effective component.

1 . A separating agent for enantiomeric isomers comprising a polysaccharide alicyclic ester derivative not having an aromatic group, wherein the polysaccharide alicyclic ester derivative is selected from the group consisting of cellulose tris(cyclohexylcarboxylate) and cellulose tris(cyclopentylcarboxylate).  
     
     
         2 . A method for separating enantiomeric isomers by a chromatography having a chiral stationary phase comprising the step of contacting the enantiomeric isomers with a chiral stationary phase containing a polysaccharide alicyclic ester derivative free from an aromatic group as an effective component, wherein the polysaccharide alicyclic ester derivative is selected from the group consisting of cellulose tris(cyclohexylcarboxylate) and cellulose tris(cyclopentylcarboxylate).  
     
     
         3 . The method according to  claim 2 , wherein the polysaccharide alicyclic ester derivative is cellulose triscyclohexylcarboxylate.  
     
     
         4 . The method according to  claim 2 , wherein the polysaccharide alicyclic ester derivative is cellulose triscyclopentylcarboxylate.  
     
     
         5 . A chiral stationary phase for chromatography comprising the separating agent of  claim 1 .  
     
     
         6 . A chiral stationary phase for reversed phase liquid chromatography comprising the chiral stationary phase of  claim 5 .  
     
     
         7 . A chiral stationary phase for thin-layer chromatography comprising the chiral stationary phase of  claim 5 .  
     
     
         8 . An asymmetry recognition agent for capillary electrophoresis comprising the chiral stationary phase of  claim 5 .  
     
     
         9 . A stationary phase for continuous liquid preparative chromatography comprising the chiral stationary phase of  claim 5 .  
     
     
         10 . The separating agent for enantiomeric isomers according to  claim 1 , wherein the alicyclic ester derivative is triscyclohexylcarboxylate.  
     
     
         11 . The separating agent for enantiomeric isomers according to  claim 1 , wherein the alicyclic ester derivative is triscyclopentylcarboxylate.