Method of inhibiting alveolar bone resorption and periodontal membrane loss and composition for internal use to be used therein

Abstract

Alveolar bone resorption, periodontal membrane loss, and gingival recession can be inhibited by administering 500 mg to 2000 mg per day of calcium, 10 mg to 40 mg per day of soy isoflavone aglycone, and vitamin D 3 to persons having a tendency for decreased bone density, postmenopausal women, and periodontal disease patients in a maintenance phase; and even an extended period of administration provides a high degree of safety.

1 . An oral composition for alveolar bone resorption inhibition and periodontal membrane loss inhibition, comprising a soy isoflavone aglycone, calcium, and vitamin D 3 .  
   
   
       2 . An agent for preventing or treating gingival recession, comprising a soy isoflavone aglycone, calcium, and vitamin D 3 .  
   
   
       3 . An agent for preventing or treating alveolar bone resorption and periodontal membrane loss, comprising a soy isoflavone aglycone, calcium, and vitamin D 3 .  
   
   
       4 . A composition or agent according to  claim 1 , wherein the proportion of soy isoflavone aglycone in the composition or agent is 0.001% to 10% by weight; and the proportion of calcium in the composition or agent is 0.01% to 50% by weight.  
   
   
       5 . A composition or agent according to  claim 1 , wherein the composition or agent is for persons having decreased bone density, postmenopausal women, or periodontal disease patients in a maintenance phase.  
   
   
       6 . A composition according to  claim 1 , wherein the soy isoflavone aglycone is an extract from whole-grain soy; the genistein/daidzein weight ratio in the soy isoflavone aglycone is in the range of 1/1 to 1.5/1; and the proportion of the total weight of genistein and daidzein in the soy isoflavone aglycone is at least 90%.  
   
   
       7 . A method for inhibiting alveolar bone resorption and periodontal membrane loss, comprising orally administering a composition according to  claim 1 .  
   
   
       8 . A method for preventing or treating gingival recession, comprising orally administering a soy isoflavone aglycone, calcium, and vitamin D 3 .  
   
   
       9 . A method for preventing or treating alveolar bone resorption and periodontal membrane loss, comprising orally administering a soy isoflavone aglycone, calcium, and vitamin D 3 .  
   
   
       10 . A method according to  claim 8 , wherein the soy isoflavone aglycone, calcium, and vitamin D 3  are administered to persons having decreased bone density, postmenopausal women, or periodontal disease patients in a maintenance phase.  
   
   
       11 . A method according to  claim 9 , wherein the soy isoflavone aglycone is administered in an amount of 10 mg to 40 mg per day; and calcium is administered in an amount of 500 mg to 2000 mg per day.  
   
   
       12 . A composition or agent according to  claim 3 , wherein the proportion of soy isoflavone aglycone in the composition or agent is 0.001% to 10% by weight; and the proportion of calcium in the composition or agent is 0.01% to 50% by weight.  
   
   
       13 . A composition or agent according to  claim 3 , wherein the composition or agent is for persons having decreased bone density, postmenopausal women, or periodontal disease patients in a maintenance phase.  
   
   
       14 . A method for inhibiting alveolar bone resorption and periodontal membrane loss, comprising orally administering a composition according to  claim 6 .  
   
   
       15 . A method according to  claim 9 , wherein the soy isoflavone aglycone, calcium, and vitamin D 3  are administered to persons having decreased bone density, postmenopausal women, or periodontal disease patients in a maintenance phase.  
   
   
       16 . A method according to  claim 10 , wherein the soy isoflavone aglycone is administered in an amount of 10 mg to 40 mg per day; and calcium is administered in an amount of 500 mg to 2000 mg per day.