US2007237825A1PendingUtilityA1

Composition for topical substance delivery

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Assignee: SOLUBLE SYSTEMS LLCPriority: May 30, 2000Filed: Apr 6, 2007Published: Oct 11, 2007
Est. expiryMay 30, 2020(expired)· nominal 20-yr term from priority
Inventors:Guy LevyAllan StaleyJames D. Rancourt
A61P 39/02A61P 3/10A61P 5/00A61P 31/18A61P 29/00A61P 31/04A61P 25/24A61P 27/04A61K 9/0014A61P 17/02A61K 9/06A61P 1/02A61P 19/02A61K 9/0048A61K 47/32A61L 26/0014A61L 26/008A61P 17/16A61P 1/00A61P 21/02C08F 220/20
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Claims

Abstract

A polymerized hydrogel composition for hydrating or dehydrating a surface, particularly a dermatological surface, to which it is applied and a method for forming the composition. The composition is comprised of a mixture of two polymerizable materials, a two-part redox catalyst system and a two-part polymerization medium. The percentage by weight of each element in the composition may be varied within stated percentage ranges and depending to the desired application. The rate at which hydration or dehydration occurs may be controllably altered by varying the percentages of certain of the composition elements and by adding either or both of a fibrous filler material and a humectant to the composition.

Claims

exact text as granted — not AI-modified
1 . A microporous hydrogel composition, comprising: 
 a microporous hydrogel polymer formed from a polymerization composition, comprising: 
 a. 26-35% by weight of a hydrophilic acrylate-based monomer selected from 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, and 2-hydroxybutyl acrylate;  
 b. a crosslinking agent;  
 c. 62-72% by weight of water;  
 d. up to 11% by weight of a low molecular weight aliphatic alcohol; and,  
 e. a predetermined amount of a fibrous filler material having known moisture absorption characteristics.  
   
     
     
         2 . The composition of  claim 1 , further comprising: 
 propylene glycol, wherein the propylene glycol is infused into the polymerized microporous hydrogel.    
     
     
         3 . The composition of  claim 2 , wherein the propylene glycol is infused into the polymerized microporous hydrogel by contacting the microporous hydrogel polymer with an aqueous solution of propylene glycol.  
     
     
         4 . The composition of  claim 3 , wherein the aqueous solution of propylene glycol, comprises 25-75% propylene glycol.  
     
     
         5 . The composition of  claim 3 , wherein the aqueous solution of propylene glycol, comprises 25% propylene glycol.  
     
     
         6 . The composition of  claim 3 , wherein the aqueous solution of propylene glycol, comprises 50% propylene glycol.  
     
     
         7 . The composition of  claim 3 , wherein the aqueous solution of propylene glycol, comprises 75% propylene glycol.  
     
     
         8 . The composition of  claim 1  wherein the fibrous filler material is insoluble in water, acrylate monomers, aliphatic alcohol, and propylene glycol.  
     
     
         9 . The composition of  claim 8  wherein the fibrous filler material is comprised of polar polymers.  
     
     
         10 . The composition of  claim 8  wherein the fibrous filler material is comprised of non-polar polymers.  
     
     
         11 . The composition of  claim 8  wherein the predetermined amount of the fibrous filler material is that amount of the material which, based on the known moisture absorption capacity of the material, will achieve moisture saturation when mixed with the other polymerization composition elements.  
     
     
         12 . The composition of  claim 1 , wherein the crosslinking agent is selected from ethylene glycol dimethacrylate (EGDMA), diethylene glycol dimethacrylate, trimethylpropane triacrylate, and trimethylpropane trimethacrylate.  
     
     
         13 . The composition of  claim 12 , wherein the crosslinking agent is EGDMA.  
     
     
         14 . The composition of  claim 1 , wherein 1-1.8% by weight of the polymerization composition is the crosslinking agent.  
     
     
         15 . The composition of  claim 14 , wherein 1.3% by weight of the polymerization composition is the crosslinking agent.  
     
     
         16 . The composition of  claim 1 , wherein 6.5% by weight of the polymerization composition is the alcohol.  
     
     
         17 . The composition of  claim 1 , wherein the microporous hydrogel polymer comprises 0% by weight of the aliphatic alcohol.  
     
     
         18 . The composition of  claim 1 , wherein the alcohol is selected from isopropyl alcohol (IPA), ethyl alcohol, and methyl alcohol.  
     
     
         19 . The composition of  claim 18 , wherein the alcohol is IPA.  
     
     
         20 . The composition of  claim 1 , wherein the polymerization composition further comprises: a polymerization initiator.  
     
     
         21 . The composition of  claim 20 , wherein the polymerization initiator is a thermally activated free radical initiator.  
     
     
         22 . The composition of  claim 21 , wherein the thermally activated free radical initiator is 2,2′-azobisisobutyronitrile.  
     
     
         23 . The composition of  claim 20 , wherein the polymerization initiator is a redox catalyst system.  
     
     
         24 . The composition of  claim 23 , wherein the redox catalyst system, comprises: 
 ammonium persulfate and tetramethylethylenediamine.    
     
     
         25 . The composition of  claim 24 , wherein 0.4% by weight of the polymerization composition of ammonium persulfate is present and 0.2% by weight of the polymerization composition of tetramethylethylenediamine is present.  
     
     
         26 . The composition of  claim 1 , wherein the monomer is 2-hydroxyethyl acrylate.  
     
     
         27 . The composition of  claim 1 , wherein the monomer is 2-hydroxypropyl acrylate.  
     
     
         28 . The composition of  claim 1 , wherein the monomer is 2-hydroxybutyl acrylate.  
     
     
         29 . A microporous hydrogel composition, comprising: 
 (A) a microporous hydrogel polymer formed from a polymerization composition; and,    (B) propylene glycol, wherein the propylene glycol is infused into the polymerized microporous hydrogel;    the polymerization composition, comprising: 
 a. 26-35% by weight of a hydrophilic acrylate-based monomer selected from 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, and 2-hydroxybutyl acrylate;  
 b. a crosslinking agent;  
 c. 62-72% by weight of water;  
 d. up to 11% by weight of a low molecular weight aliphatic alcohol; and,  
 e. a predetermined amount of a fibrous filler material having known moisture absorption characteristics.  
   
     
     
         30 . The composition of  claim 29 , wherein the propylene glycol is infused into the polymerized microporous hydrogel by contacting the microporous hydrogel polymer with an aqueous solution of propylene glycol.  
     
     
         31 . The composition of  claim 30 , wherein the aqueous solution of propylene glycol, comprises 25-75% propylene glycol.  
     
     
         32 . The composition of  claim 30 , wherein the aqueous solution of propylene glycol, comprises 25% propylene glycol.  
     
     
         33 . The composition of  claim 30 , wherein the aqueous solution of propylene glycol, comprises 50% propylene glycol.  
     
     
         34 . The composition of  claim 30 , wherein the aqueous solution of propylene glycol, comprises 75% propylene glycol.  
     
     
         35 . The composition of  claim 29  wherein the fibrous filler material is insoluble in water, acrylate monomers, aliphatic alcohol, and propylene glycol.  
     
     
         36 . The composition of  claim 35  wherein the fibrous filler material is comprised of polar polymers.  
     
     
         37 . The composition of  claim 35  wherein the fibrous filler material is comprised of non-polar polymers.  
     
     
         38 . The composition of  claim 35  wherein the predetermined amount of the fibrous filler material is that amount of the material which, based on the known moisture absorption capacity of the material, will achieve moisture saturation when mixed with the other polymerization composition elements.  
     
     
         39 . The composition of  claim 29 , wherein the crosslinking agent is selected from ethylene glycol dimethacrylate (EGDMA), diethylene glycol dimethacrylate, trimethylpropane triacrylate, and trimethylpropane trimethacrylate.  
     
     
         40 . The composition of  claim 39 , wherein the crosslinking agent is EGDMA.  
     
     
         41 . The composition of  claim 29 , wherein 1-1.8% by weight of the polymerization composition is the crosslinking agent.  
     
     
         42 . The composition of  claim 41 , wherein 1.3% by weight of the polymerization composition is the crosslinking agent.  
     
     
         43 . The composition of  claim 29 , wherein 6.5% by weight of the polymerization composition is the alcohol.  
     
     
         44 . The composition of  claim 29 , wherein the microporous hydrogel polymer comprises 0% by weight of the aliphatic alcohol.  
     
     
         45 . The composition of  claim 29 , wherein the alcohol is selected from isopropyl alcohol (IPA), ethyl alcohol, and methyl alcohol.  
     
     
         46 . The composition of  claim 45 , wherein the alcohol is IPA.  
     
     
         47 . The composition of  claim 29 , wherein the polymerization composition further comprises: a polymerization initiator.  
     
     
         48 . The composition of  claim 47 , wherein the polymerization initiator is a thermally activated free radical initiator.  
     
     
         49 . The composition of  claim 48 , wherein the thermally activated free radical initiator is 2,2′-azobisisobutyronitrile.  
     
     
         50 . The composition of  claim 47 , wherein the polymerization initiator is a redox catalyst system.  
     
     
         51 . The composition of  claim 50 , wherein the redox catalyst system, comprises: 
 ammonium persulfate and tetramethylethylenediamine.    
     
     
         52 . The composition of  claim 51 , wherein 0.4% by weight of the polymerization composition of ammonium persulfate is present and 0.2% by weight of the polymerization composition of tetramethylethylenediamine is present.  
     
     
         53 . The composition of  claim 29 , wherein the monomer is 2-hydroxyethyl acrylate.  
     
     
         54 . The composition of  claim 29 , wherein the monomer is 2-hydroxypropyl acrylate.  
     
     
         55 . The composition of  claim 29 , wherein the monomer is 2-hydroxybutyl acrylate.

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