US2007270447A1PendingUtilityA1

Compositions and methods for coating medical implants

Assignee: ANGIOTECH INT AGPriority: May 24, 2002Filed: Jul 31, 2007Published: Nov 22, 2007

Est. expiryMay 24, 2022(expired)· nominal 20-yr term from priority

Inventors:William L. Hunter David Gravett Philip M. Toleikis Richard Liggins Troy Loss

A61L 2300/416A61L 27/34A61P 43/00A61L 2300/404A61L 29/16A61P 31/00A61L 29/085A61L 27/54

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Abstract

Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.

Claims

exact text as granted — not AI-modified

1 . A composition, comprising a polymer and a fluoropyrimidine wherein said fluoropyrimidine is present in said composition at a concentration of less than 10 −4  M.  
     
     
         2 . The composition according to  claim 1  wherein said fluoropyrimidine is present in said composition at a concentration of less than any one of 10 −5  M, 10 −6  M, or 10 −7  M.  
     
     
         3 . The composition according to  claim 1  wherein said polymer is a non-biodegradable polymer.  
     
     
         4 . The composition according to  claim 1  wherein said polymer is a polyurethane.  
     
     
         5 . The composition according to  claim 1  wherein said polymer is a poly(lactide-co-glycolide).  
     
     
         6 . The composition according to  claim 1  wherein said fluoropyrimidine is 5-fluorouracil.

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