Systems and methods for modulating autonomic function

Abstract

In one embodiment, a method for modulating a person's autonomic function comprises interfacing a valve system to the person's airway, the valve system being configured to decrease or prevent respiratory gas flow to the person's lungs during at least a portion of an inhalation event. The person is permitted to inhale and exhale through the valve system, wherein during inhalation the valve system functions to produce a vacuum within the thorax to transiently decrease intrathoracic pressure and thereby modulate the person's autonomic function.

1 - 22 . (canceled)  
   
   
       23 . A method for altering a person's intracranial pressure to thereby modulate the person's autonomic tone, the method comprising: 
 interfacing a valve system to the person's airway, the valve system being configured to decrease or prevent respiratory gas flow to the person's lungs during at least a portion of an inhalation event;    permitting the person to inhale and exhale through the valve system, wherein during inhalation the valve system functions to produce a vacuum within the thorax to transiently decrease intrathoracic pressure, decrease intracranial pressure and thereby modulate the person's autonomic tone;    wherein the valve system includes a pressure responsive inflow valve, and further comprising setting an actuating pressure of the valve to be in the range from about −2 cm H2O to about −30 cm H2O.    
   
   
       24 . A method as in  claim 23 , further comprising setting the actuating pressure of the valve to be in the range from about −3 cm H2O to about −12 cm H2O for flow rates between about 30 to about 50 liters per minute.  
   
   
       25 . A method as in  claim 23 , wherein during inhalation the valve system functions to decrease the person's heart rate and peripheral vascular tone.  
   
   
       26 . A method as in  claim 23 , wherein during inhalation the valve system functions to increase blood flow back to the right heart of the person, thereby enhancing vital organ perfusion and function.  
   
   
       27 . A method as in  claim 23 , wherein during inhalation the valve system functions to increase heart rate variability.  
   
   
       28 . A method as in  claim 23 , wherein during inhalation the valve system functions to reduce the person's anxiety level.  
   
   
       29 . A method as in  claim 23 , wherein during inhalation the valve system functions to treat shock secondary to hypovolemia, sepsis and heart failure.  
   
   
       30 . A method as in  claim 23 , wherein during inhalation the valve system functions to treat states of hypo-perfusion that are selected from a group consisting of wound healing, stroke and diseases where blood flow is compromised, wherein at least one of the diseases comprises coronary artery disease.  
   
   
       31 . A method as in  claim 23 , wherein during inhalation the valve system functions to improve blood flow to the muscles and brain, thereby reducing heart rate and enhancing recovery from physical exertion.  
   
   
       32 . A method as in  claim 23 , wherein the valve system is incorporated into a facial mask or a mouthpiece, and further comprising coupling the facial mask or the mouthpiece to the person's face.  
   
   
       33 . A method as in  claim 23 , further comprising coupling at least one physiological sensor to the patient to monitor at least one physiological parameter of the person while breathing through the valve system, and varying the actuating pressure based on the monitored physiological parameter.  
   
   
       34 . A method for repetitively increasing a person's sympathetic tone to prevent hypotension, the method comprising: 
 interfacing a valve system to the person's airway, the valve system being configured to decrease or prevent respiratory gas flow to the person's lungs during at least a portion of an inhalation event;    permitting the person to inhale and exhale through the valve system, wherein during inhalation the valve system functions to produce a vacuum within the thorax to improve blood flow to the muscles and brain, and to increase the person's sympathetic tone to prevent hypotension;    wherein the valve system includes a pressure responsive inflow valve, and further comprising setting an actuating pressure of the valve to be in the range from about −2 cm H2O to    
   
   
       35 . A method for repetitively increasing a person's sympathetic tone to prevent hypotension, the method comprising: 
 interfacing a valve system to the person's airway, the valve system being configured to decrease or prevent respiratory gas flow to the person's lungs during at least a portion of an inhalation event;    permitting the person to inhale and exhale through the valve system, wherein during inhalation the valve system functions to produce a vacuum within the thorax to improve blood flow to the muscles and brain, and to increase the person's sympathetic tone to prevent hypotension;    wherein the valve system includes a pressure responsive inflow valve, and further comprising setting an actuating pressure of the valve to be in the range from about −2 cm H2O to about −30 cm H2O; and    measuring one or more physiological parameters before and after a period of inhalation through the valve system to thereby evaluate the patient's condition based on a change of such measured parameters.