Use of chemical chelators as reversal agents for drug-induced neuromuscular block

Abstract

The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having the general formula A wherein R is the general formula B wherein X is or a pharmaceutically acceptable salt thereof.

1 - 33 . (canceled)  
   
   
       34 . A method for reversal of drug-induced neuromuscular block in a patient caused by clinically-used neuromuscular blocking agent which acts by reversible binding to the acetylcholine receptor, comprising parenterally administering to said patient an effective amount of a chemical chelator capable of forming a guest-host complex with the neuromuscular blocking agent, wherein the association constant of said guest-host in an aqueous medium at ambient temperature is higher than 10.000 M-1.  
   
   
       35 . The method according to  claim 34 , wherein the neuromuscular blocking agent is selected from the group consisting of rocuronium, vecuronium, pancuronium, rapacuronium, mivacurium, (cis)atracurium and tubocurarine.  
   
   
       36 . The method according to  claim 34 , wherein the chemical chelator is selected from the group consisting of cyclic oligosaccharides and cyclophanes.  
   
   
       37 . The method according to  claim 34 , wherein the chemical chelator is gamma-cyclodextrin or a derivative thereof.  
   
   
       38 . The method according to  claim 34 , wherein the neuromuscular blocking agent is selected from the group consisting of rocuronium and vecuronium and the chemical chelator is gamma-cyclodextrin or a derivative thereof.