Method and preparation for binding aldehydes in saliva

Abstract

The object of the invention is the use of compounds comprising one or more free sulphlydryl or amino groups for preparing a pharmaceutical composition for locally binding acetaldehyde in saliva, the stomach or the large intestine, and pharmaceutical compositions comprising the said compounds.

1 - 40 . (canceled)  
     
     
         41 . A method for decreasing the risk of cancer of the mouth and pharynx, or larynx, oesophagus and stomach, comprising administering to a smoking subject, a composition comprising: 
 (A) an effective amount of an aldehyde binding substance(s) comprising one or more free sulphhydryl and amino groups, and    (B) a carrier,    wherein upon administering, said composition releases said aldehyde binding substance(s) into saliva of said subject, whereby aldehyde in said saliva is bound by said aldehyde binding substance(s) during smoking by said subject.    
     
     
         42 . The method according to  claim 41 , wherein said administering results in lowering of the amount of aldehyde during smoking of one cigar, cigarette or pipe essentially to the level of aldehyde in saliva before smoking.  
     
     
         43 . The method according to  claim 41 , wherein the carrier is selected from the group consisting of a pharmaceutically acceptable diluent, sweetening agent, flavouring agent and lubricant/glident.  
     
     
         44 . The method according to  claim 41 , wherein the composition is in a preparation form selected from the group consisting a chewable tablet, buccal tablet, sublingual tablet, candy, pastille, lozenge, chewing gum, bubble gum and gel.  
     
     
         45 . The method according to  claim 44 , wherein during smoking by said subject, at least one of said preparation form is placed in the mouth of said subject, wherein said preparation form releases aldehyde-binding substance(s) to saliva essentially during the time when 1 tobacco product is smoked by said subject.  
     
     
         46 . The method according to  claim 41 , wherein the composition is attached to a tobacco product, tobacco filter or a tobacco holder.  
     
     
         47 . The method according to  claim 46 , wherein the composition is attached to that part of a tobacco product, tobacco filter or tobacco holder which is put to the mouth of said subject during smoking.  
     
     
         48 . The method according to  claim 46 , wherein the composition comes into contact with saliva during smoking by said subject, and said composition releases aldehyde-binding substance(s) to saliva essentially during the time when 1 tobacco product is smoked by said subject.  
     
     
         49 . The method according to  claim 46 , wherein the composition is detachable from the tobacco product, tobacco filter or tobacco holder.  
     
     
         50 . The method according to  claim 41 , wherein the carrier allows for the release of the aldehyde-binding substance(s) to saliva within less than 30 minutes after administration.  
     
     
         51 . The method according to  claim 41 , wherein the aldehyde-binding substance(s) is represented by the following formula:  
         R 1 —NH—CH—COOH  
       (CH 2 ) n —R 2    
       wherein 
 R 1  is hydrogen or an acyl group containing 1-4 carbon atoms,  
 R 2  is a sulphhydryl group or sulphonic acid, and  
 n is 1 or 2.  
 
     
     
         52 . The method according to  claim 41 , wherein the aldehyde-binding substance(s) is selected from the group consisting of L-cysteine, D-cysteine, cystine, cysteic acid, cysteine glycine, threo- or erythro-β-phenyl-DL-cysteine, B-tetramethylene-DL-cysteine, methionine, D-penicillamine and its N-terminal dipeptides, semicarbazide, reduced glutathione, β-mercaptoethylamine, D 5 L-homocysteine, N-acetylcysteine, L-cysteinyl-L-valine, β,β-tetramethylene-DL-cysteine, cysteinyl glycine, mercaptoethyl glycine, tre-(5)-β-phenyl-DL-cysteine, erythro-β-phenyl-DL-cysteine, thiamine hydrochloride and mercaptane.  
     
     
         53 . The method according to  claim 41 , wherein said aldehyde-binding substance(s) binds aldehyde both through a sulphhydryl and an amino group.  
     
     
         54 . The method according to  claim 41 , wherein said aldehyde-binding substance(s), is selected from the group consisting of L-cysteine, D-cysteine, a derivative of cysteine and a substance that is capable of converting to cysteine.  
     
     
         55 . The method according to  claim 41 , wherein said aldehyde is acetaldehyde.  
     
     
         56 . A tobacco product, tobacco filter or tobacco holder for use in binding-aldehyde in saliva during smoking comprising a composition comprising an aldehyde-binding substance(s) comprising one or more free sulphhydryl and amino groups, attached thereto in an amount capable of lowering aldehyde in saliva during smoking essentially to a level of aldehyde before smoking.  
     
     
         57 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the composition is attached to that part of a tobacco product, tobacco filter or tobacco holder which is put to the mouth during smoking.  
     
     
         58 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the composition comprises a carrier selected from the group consisting of a pharmaceutically acceptable diluent, sweetening agent, flavouring agent and lubricant/glident.  
     
     
         59 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the composition is in a preparation form selected from the group consisting of a chewable tablet, buccal tablet, sublingual tablet, candy, pastille, lozenge, chewing gum, bubble gum and gel.  
     
     
         60 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the composition is attached to a tobacco product, tobacco filter or tobacco holder with or without an adhesive like-material.  
     
     
         61 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the composition is attached so that the composition remains in contact with the tobacco product, tobacco filter or tobacco holder.  
     
     
         62 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the composition is attached by impregnating and/or concentrating and/or drying the composition to a tobacco product, tobacco filter or tobacco holder.  
     
     
         63 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the aldehyde-binding substance(s) is present in a higher concentration on the surface of said tobacco product, tobacco filter or tobacco holder than inside of said tobacco product, tobacco filter or tobacco holder.  
     
     
         64 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the composition is attached to the surface of a tobacco product, tobacco filter or tobacco holder.  
     
     
         65 . The tobacco product, tobacco filter or tobacco holder according to  claim 56 , wherein the tobacco product is a cigar or a cigarette, the tobacco filter is a cigarette filter, and the tobacco holder is a pipe.  
     
     
         66 . A kit comprising: 
 (A) a plurality of cigars or cigarettes, and    (B) a plurality of preparations comprising an aldehyde binding substance(s) comprising one or more free sulphhydryl and amino groups, in an amount capable of lowering aldehyde in saliva during smoking essentially to a level of aldehyde before smoking.    
     
     
         67 . The kit according to  claim 66 , wherein the preparation(s) is capable of lowering aldehyde in saliva during smoking of 1, 2 or 3 cigars or cigarettes.