Dose packaging system for load-dose titration administration of a liquid formulation

Abstract

The invention generally relates to a dose packaging system for the administration of a liquid formulation to a patient requiring load-dose titration therapy of a pharmaceutically active drug, such as steroid therapy. More particularly, the invention relates to a dose packaging system for administering titration therapy of liquid formulations to a patient which eliminates the disadvantages that are associated with cups, dosing spoons, calibrated oral syringes and bottles.

1 . A dose package system for administering a load-dose titration therapy to a patient afflicted with a condition, said system comprising: 
 a plurality of ampoules containing a pharmaceutically effective dose of a liquid formulation;    a backing card; and    wherein said backing card includes two or more sections containing an appropriate number of ampoules such that each section of said backing card corresponds to a daily dose of the liquid formulation to be administered to the patient and wherein at least one of said sections has a different number of ampoules than at least one other of said section.    
     
     
         2 . The package system of  claim 1 , further comprising a cover sheet to retain said ampoules onto said backing card.  
     
     
         3 . The package system of  claim 2 , wherein said cover sheet is transparent.  
     
     
         4 . The package system of  claim 2 , wherein said cover sheet is a skin package.  
     
     
         5 . The package system of  claim 2 , wherein the cover sheet is a shrink package.  
     
     
         6 . The package system of  claim 1 , wherein said backing card has a weakened portion along a perimeter of said ampoules.  
     
     
         7 . The package system of  claim 3 , wherein the weakened portion is a perforated portion.  
     
     
         8 . The package system of  claim 1 , wherein said backing card is cardboard.  
     
     
         9 . The package system of  claim 1 , wherein the load-dose titration therapy is load-dose upward titration therapy.  
     
     
         10 . The package system of  claim 1 , wherein the load-dose titration therapy is load-dose downward titration therapy.  
     
     
         11 . The package system of  claim 1 , wherein the load-dose titration therapy is a 5-day regimen.  
     
     
         12 . The package system of  claim 1 , wherein the load-dose titration therapy is a 6-day regimen.  
     
     
         13 . The package system of  claim 1 , wherein the ampoule is a blow-fill seal vial.  
     
     
         14 . The package system of  claim 13 , wherein the blow-fill seal vial is fabricated from plastic.  
     
     
         15 . The package system of  claim 1 , wherein the liquid formulation includes an effective amount of prednisolone.  
     
     
         16 . The package system of  claim 1 , wherein said ampoules are pre-filled with about 5 ml of a liquid formulation.  
     
     
         17 . The package system of  claim 1 , wherein said ampoules are filled with about 2.5 ml of a liquid formulation.  
     
     
         18 . The package system of  claim 1 , wherein the patient is afflicted with at least one condition selected from the group consisting of asthma, acute lower respiratory tract infection, pneumonia, infant respiratory distress syndrome, adult respiratory distress syndrome, croup, bronchitis, and pertussis.  
     
     
         19 . The package system of  claim 1 , wherein the patient is a child.  
     
     
         20 . The package system of  claim 1 , wherein the packaging system is a box.