Compositions and Methods for the Treatment of Inflammatory Conditions of the Mucosae, Skin and the Eye

Abstract

The present invention relates to compositions comprising a proanthocyanidin, as well as methods for using such compositions in the treatment of an inflammatory condition of the skin including, but not limited to, atopic dermatitis(eczema), allergic contact dermatitis, seborrheic dermatitis, psoriasis, xerosis and atopia, as well as treatment of an inflammatory condition of mucosae and of an inflammatory condition in the eye. The present invention also relates to compositions comprising a proanthocyanidin, glycyrrhetinic acid and telmesteine, as well as methods for using such compositions in the treatment of an inflammatory condition of the skin including, but not limited to, atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, radiation dermatitis, psoriasis, xerosis and atopia, as well as treatment of an inflammatory condition of mucosae and of an inflammatory condition in the eye.

1 . A composition comprising a proanthocyanidin, glycyrrhetinic acid, telmesteine, and a pharmaceutically acceptable carrier.  
   
   
       2 . The composition according to  claim 1 , wherein the composition is in the form of a cream, a gel, a lotion, a suspension, a spray, an ointment, or a foam.  
   
   
       3 . The composition according to  claim 1 , wherein the composition further comprises a wetting agent.  
   
   
       4 . The composition according to  claim 1 , wherein the composition further comprises one or more of squalene, karite butter, octyl palmitate, or oenothera oil.  
   
   
       5 . The composition according to  claim 1 , wherein the composition further comprises a tocopherol, ascorbic acid, or an ester thereof.  
   
   
       6 . The composition according to  claim 5 , wherein the composition further comprises tocopherol acetate, ascorbyl palmitate or tetrapalmitate.  
   
   
       7 . The composition according to  claim 1 , wherein the composition further comprises salicylic acid.  
   
   
       8 . The composition according to  claim 1 , wherein the composition further comprises hyaluronic acid.  
   
   
       9 . The composition according to  claim 1 , wherein the composition further comprises at least one compound selected from the group consisting of alpha-bisabolol, zinc picolate, allantoin, and piroctone olamine.  
   
   
       10 . The composition according to  claim 1 , wherein the proanthocyanidin is in a complex with phospholipids.  
   
   
       11 . The composition according to  claim 10 , wherein the proanthocyanidin in complex with phospholipids is present in the composition at a concentration range of about 0.01% to about 1%.  
   
   
       12 . The composition according to  claim 1 , wherein glycyrrhetinic acid is present in the composition at a concentration range of about 0.1% to about 5%.  
   
   
       13 . The composition according to  claim 1 , wherein telmesteine is present in the composition at a concentration range of about 0.01% to about 1%.  
   
   
       14 . A composition comprising about 0.1% proanthocyanidins in a complex with phospholipids, about 0.8% glycyrrhetinic acid, about 0.1% telmesteine, about 7.0% octyl palmitate, about 5.0% pentylene glycol, about 4.0% karite butter, about 4.0% arachidyl alcogol, behenyl alcohol, C12-20 alkylglucoside, about 3.0% glyceryl stearate and glyceryl (100) stearate, about 2.0% oenothera oil, about 1.5% vapriloyl glycine, about 1.2% bisabolol, about 1.0% vitamin E acetate, about 0.7% carbomer, about 0.6% octyl glycerin, about 0.5% salicylic acid, about 0.5% octopirox, about 0.387% sodium hydroxide, about 0.35% allantoin, about 0.1% zinc picolate, about 0.08% EDTA disodium salt, about 0.05% ascorbyl palmitate, about 0.02% propyl gallage, and about 65.013% water.  
   
   
       15 . A method for treating or preventing atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, xerosis; psoriasis or atopia comprising topically administering a composition comprising proanthocyanidins to a subject in need of such treatment or prevention in an amount effective to treat or prevent atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, xerosis, psoriasis or atopia.  
   
   
       16 . The method according to  claim 15 , wherein the composition further comprises glycyrrhetinic acid and telmesteine.  
   
   
       17 . The method according to  claim 15 , wherein the proanthocyanidins are in a complex with phospholipids.  
   
   
       18 . The method according to  claim 15 , wherein the composition further comprises one or more agents selected from the group consisting of a wetting agent, salicylic acid, allantoin, hyaluronic acid, zinc pidolate, alpha-bisabolol, and piroctone olamine.  
   
   
       19 . A method for treating or preventing an inflammatory condition of the mucosae, skin or the eye comprising topically administering a composition comprising proanthocyanidin, glycyrrhetinic acid and telmesteine to a subject in need of such treatment or prevention in an amount effective to treat or prevent the inflammatory condition.  
   
   
       20 . The method according to  claim 19 , wherein the composition further comprises one or more agents selected from the group consisting of a wetting agent, salicylic acid, allantoin, hyaluronic acid, zinc picolate, alpha-bisabolol, and piroctone olamine.  
   
   
       21 . The method according to  claim 19 , wherein the proanthocyanidins are in a complex with phospholipids.  
   
   
       22 . The method according to  claim 19 , wherein the inflammatory condition is selected from the group consisting of atopic dermatitis, allergic contact dermatitis, seborrheic dermatitis, radiation dermatitis, xerosis; psoriasis and atopia.  
   
   
       23 . The method according to  claim 19 , wherein the administration is vaginal, rectal, buccal or in the eye.  
   
   
       24 . The method according to  claim 19 , wherein the inflammatory condition is selected from the coup consisting of dermatitis conditions and skin impairments such as atopic dermatitis, contact dermatitis, allergic contact dermatitis, allergic dermatitis, seborrheic dermatitis, nummular dermatitis, chronic dermatitis of hands or feet, generalized exfoliative dermatitis, stasis dermatitis, neonatal dermatitis, pediatric dermatitis, localized scratch dermatitis, toxic/irritating contact eczema, allergic contact eczema, type I or type IV photoallergic contact eczema, contact urticaria, dyshidrosiform eczema, age-caused wrinkles, sun damage itching, psoriasis vulgaris, flaking eczema, psoriasis pustulosa, psoriasis arthropatica, psoriatic erythroderma, rosacea, photodermatosis, radiodermatitis acuta and chronica (UV and ionizing radiation therapy), chronic actinic dermatitis, photouticaria (uticaria solaris), polymorphic photodermatosis, prurigo (strophulus, uticaria papulosa), subacuta, chronica, acne vulgaris, juvenile and adult (acne with comedones, papulous, pustulous, nodose, i.e., nodular, nodulocystic acne), acne conglobata (special form: hidradenitis suppurativa), acne fulminans, acne tetrad, acne neonatorum, senile acne, mechanical acne forms (excoriated acne), acne cosmetica, folliculitis with superinfected acne (Staphylococci), occupation-related acne forms (for example chlorine acne), decubitis, ulcus cruris, deficient ipoactive skin, localized scratch dermatitis rinophyma, ichthyosis, xerosis, and perioral dermatits.