Packages for ophthalmic lenses containing pharmaceutical agents

Abstract

A packaging for an ophthalmic lens containing a pharmaceutical agent.

1 . A blister bowl for packaging ophthalmic lens comprising pharmaceutical agents wherein said blister bowl comprises a material that absorbs less than about 16% of said pharmaceutical agents, with the proviso that the material is not essentially a perfluoropolymer.  
   
   
       2 . The blister bowl of  claim 1  wherein said material absorbs between about 8% and about 3% said pharmaceutical agents.  
   
   
       3 . The blister bowl of  claim 1  wherein said material absorbs between about 5% and about 1% pharmaceutical agents.  
   
   
       4 . The blister bowl of  claim 1  wherein said material is selected from the group consisting of polysulfone, polyetherimide and polycarbonate co-polymers  
   
   
       5 . The blister bowl of  claim 1  wherein said materials are selected from the group consisting of polysulfone polymers having a glass transition temperature of greater than about 180° C.  
   
   
       6 . The blister bowl of  claim 1  wherein said materials are selected from the group consisting of polycarbonate co-polymers having a glass transition temperature of greater than about 140° C.  
   
   
       7 . The blister bowl of  claim 1  wherein said materials are selected from the group consisting of polyetherimide having a glass transition temperature of greater than about 220° C.  
   
   
       8 . The blister bowl of  claim 1  wherein the pharmaceutical agent is an antihistamine selected from the group consisting of acrivastine, antazoline, astemizole, azatadine, azelastine, brompheniramine, buclizine, burimamide, carbinoxamine, carebastine, cetirizine, chlorcyclizine, chlorpheniramine, cimetidine, ciproxifam, clemastine, clobenpropit, clozapine, cyclizine, cyproheptadine, desbrompherniramine, desloratadine, dexbrompheniramine, dexchlorpherniramine, diphenhydramine, doxylamine, dimenhydrinate, dimethindene, diphenhydramine, diphenylpyraline, doxylamine, ebastine, efletirizine, emedastine, epinastine, famotidine, fexofenadine, hydroxyzine, impentamine, iodoaminopotentidine, iodophenpropit, ketotifen, levocabastine, levoceterizine, loratadine, meclizine, mepyramine, mequitazine, methdilazine, methapyrilene, mianserin, mifetidine, mizolastine, norastemizole, norebastine, olopatadine, pheniramine, phenyltoxamine, picumast, promethazine, pyrilamine, pyrrobutamin, rantidine, R-sopromidine, S-sopromidine, tecastemizole, temelastine, terfenadine, thiethylperazine, tiotidine, trimeprazine, tripelennamine, thioperamide, triprolidine and pharmaceutically acceptable salts thereof.  
   
   
       9 . The blister bowl of  claim 1  wherein the pharmaceutical agent is ketotifen.  
   
   
       10 . The blister bowl of  claim 1  wherein the ophthalmic lens is an etafilcon A lens.  
   
   
       11 . A method of storing an ophthalmic lens comprising a pharmaceutical agent, wherein the method comprises placing said ophthalmic lens in a blister bowl and covering said blister bowl with a cover, wherein said blister bowl comprises a material that absorbs less than about 16% of said pharmaceutical agents, with the proviso that the material of the blister bowl is not essentially a perfluoropolymer.  
   
   
       12 . The method of  claim 11  wherein the cover comprises an adhesive laminate, comprising an inner layer.  
   
   
       13 . The method of  claim 12  wherein said inner layer comprises polysulfone having a glass transition temperature of greater than about 180° C.  
   
   
       14 . The method of  claim 12  wherein said inner layer comprises polycarbonate co-polymer having a glass transition temperature of greater than about 140° C.  
   
   
       15 . The method of  claim 11  wherein said blister bowl comprises a material that absorbs less than about 10% of said pharmaceutical agents  
   
   
       16 . The method of  claim 11  wherein said material is selected from the group consisting of polysulfone and polycarbonate co-polymers  
   
   
       17 . The method of  claim 11  wherein said polysulfone has a glass transition temperature of greater than about 180° C.  
   
   
       18 . The method of  claim 11  wherein said polycarbonate co-polymer has a glass transition temperature of greater than about 140° C.  
   
   
       19 . The method of  claim 11  wherein said blister bowl comprises a material that absorbs between less than about 8% and about 3% of said pharmaceutical agents.  
   
   
       20 . The method of  claim 11  wherein said blister bowl comprises a material that absorbs less than about 3% and about 1% of said pharmaceutical agents.  
   
   
       21 . A blister bowl for packaging ophthalmic lens comprising pharmaceutical agents wherein said blister bowl comprises a lens contacting surface and an outer surface wherein said lens contacting surface comprises a material that absorbs less than about 16% of said pharmaceutical agents and outer surface comprises a vapor barrier material, with the proviso that the material of the lens contacting surface is not essentially a perfluoropolymer.  
   
   
       22 . The blister bowl of  claim 21  wherein said lens contacting surface comprises a material that absorbs between about 8% and about 3% said pharmaceutical agents.  
   
   
       23 . The blister bowl of  claim 21  wherein said lens contacting surface comprises a material that absorbs between about 5% and about 1% pharmaceutical agents.  
   
   
       24 . The blister bowl of  claim 21  wherein said lens contacting surface comprises a material selected from the group consisting of polysulfone and polycarbonate co-polymers  
   
   
       25 . The blister bowl of  claim 21  wherein said lens contacting surface comprises a material selected from the group consisting of polysulfone polymers having a glass transition temperature of greater than about 180° C.  
   
   
       26 . The blister bowl of  claim 21  wherein said lens contacting surface comprises a material selected from the group consisting of polycarbonate co-polymers having a glass transition temperature of greater than about 140° C.  
   
   
       27 . The blister bowl of  claim 21  wherein said vapor barrier materials comprise polypropylene.  
   
   
       28 . The blister bowl of  claim 21  wherein said vapor barrier materials comprise an alicyclic co-polymer containing two different alicyclic monomers.  
   
   
       29 . The blister bowl of  claim 21  wherein the outer surface comprises at least two layers of vapor barrier materials.  
   
   
       30 . The blister bowl of  claim 29  wherein one of said vapor barrier materials is polypropylene.