Antimicrobial hand wash

Abstract

An antimicrobial hand wash includes a soap, an antimicrobial agent, and an amine salt. The amine salt is found to increase the antimicrobial efficacy of the hand wash. The amine salt produced through the reaction of monoethanolamine and lactic acid is of particular interest as a soap addition. In processes of this invention, it is possible to create the desired amine salt in the soap in situ.

1 . An antimicrobial hand wash comprising:
 a soap; and   the reaction product of a nitrogenous base neutralized with a neutralizing acid selected from anhydrides, organic acids, and inorganic acids.   
     
     
         2 . The antimicrobial hand wash of  claim 1 , wherein said soap is produced through a saponification reaction between a primary base and a primary fatty acid, wherein said primary base is selected from the group consisting of hydroxides; ammonia, alcohol-containing nitrogenous bases; oxides of group I elements, calcium, strontium, or barium; and conjugated bases of weak acids; and said primary fatty acid is selected from the group consisting of fatty acids derived from crude fats and carboxylic acids having from 6 to 40 carbon atoms in the main fatty chain. 
     
     
         3 . The antimicrobial hand wash of  claim 2 , wherein said primary base is a nitrogenous base selected from 2-aminobutanol, aminoethyl propanediol, aminomethyl propanol, aminopropanediol, bis-hydroxyethyl tromethamine, butyl diethanolamine, butylethanolamine, dibutyl dthanolamine, diethanolamine, diisopropanolamine, diisopropylamine, dimethyl isopropanolamine, monoethanolamine, dimethyl monoethanolamine, ethyl ethanolamine, isopropanolamine, isopropylamine, methylethanolamine, methylglucamine, morpholine, triethanolamine, triispropanolamine, tromethamine, and mixtures thereof. 
     
     
         4 . The antimicrobial hand wash of  claim 3 , wherein said primary fatty acid is a carboxylic acid selected from the group consisting of arachidic acid, arachidonic acid, beeswax acid, behenic acid, capric acid, caproic acid, caprylic acid, C10-40 hydroxyalkyl acid, C32-36 isoalkyl acid, coconut acid, corn acid, cottonseed acid, erucic acid, hydrogenated coconut acid, hydrogenated menhaden acid, hydrogenated palm acid, hydrogenated tallow acid, hydroxystearic acid, isomerized linoleic acid, isomerized safflower acid, isostearic acid, lauric acid, linoleic acid, myristic acid, oleic acid, olive acid, palm acid, palmitic acid, palm kernel acid, peanut acid, pelargonic acid, rapeseed acid, rice bran acid, ricinoleic acid, safflower acid, soy acid, stearic acid, sunflower seed acid, tall oil acid, tallow acid, undecanoic acid, undecylenic acid, and wheat germ acid. 
     
     
         5 . The antimicrobial hand wash of  claim 4 , wherein said primary base is monoethanolamine. 
     
     
         6 . The antimicrobial hand wash of  claim 1 , wherein said nitrogenous base neutralized with said neutralizing agent is selected from ammonia and alcohol-containing nitrogenous bases. 
     
     
         7 . The antimicrobial hand wash of  claim 6 , wherein said nitrogenous base neutralized with said neutralizing agent is selected from selected from 2-aminobutanol, aminoethyl propanediol, aminomethyl propanol, aminopropanediol, bis-hydroxyethyl tromethamine, butyl diethanolamine, butylethanolamine, dibutyl dthanolamine, diethanolamine, diisopropanolamine, diisopropylamine, dimethyl isopropanolamine, monoethanolamine, dimethyl monoethanolamine, ethyl ethanolamine, isopropanolamine, isopropylamine, methylethanolamine, methylglucamine, morpholine, triethanolamine, triispropanolamine, tromethamine, and mixtures thereof. 
     
     
         8 . The antimicrobial hand wash of  claim 7 , wherein said nitrogenous base neutralized with said neutralizing acid is monoethanolamine. 
     
     
         9 . The antimicrobial hand wash of  claim 8 , wherein said neutralizing acid is lactic acid. 
     
     
         10 . The antimicrobial hand wash of  claim 6 , wherein said neutralizing acid is selected from the group consisting of carboxylic acids, organic acid anhydrides and mixed acid anhydrides. 
     
     
         11 . The antimicrobial hand wash of  claim 10 , wherein said neutralizing acid is selected from the group consisting of acetic acid, lactic acid, glycolic acid, acetylsalicylic acid, nicotinic acid, benzoic acid, isopropanoic acid, oxalic acid, succinic acid, benzoic acid anhydride, mixed phosphoanhydride, and mixtures thereof. 
     
     
         12 . The antimicrobial hand wash of  claim 1 , further comprising an antimicrobial agent selected from the group consisting of bisguanidines, quaternary ammonium compounds, benzyl alcohols, trihalocarbanilides, iodine containing compounds, phenolic compounds, and mixtures thereof. 
     
     
         13 . The antimicrobial hand wash of  claim 12 , wherein said antimicrobial agent is a phenolic compound. 
     
     
         14 . An antimicrobial hand wash comprising:
 a soap;   an antimicrobial agent; and   the reaction product of monoethanolamine neutralized with lactic acid.   
     
     
         15 . A process for producing an antimicrobial hand wash comprising the steps of:
 producing a soap through the saponification of a primary fatty acid with a primary nitrogenous base, wherein the mole to mole ratio for alkalinity of the primary nitrogenous base to free primary fatty acid is from about 1.5:1 to 3:1 such that there exists an excess of primary nitrogenous base after the saponification;   reacting the excess primary nitrogenous base with a secondary acid selected from the group consisting of carboxylic acids, organic acid anhydrides and mixed acid anhydrides to create an amine salt.   
     
     
         16 . The process of  claim 15 , wherein the primary fatty acid is selected from the group consisting of fatty acids derived from crude fats and carboxylic acids having from 6 to 40 carbon atoms in the main fatty chain. 
     
     
         17 . The process of  claim 15 , further comprising the steps of:
 dissolving a phenol-based antimicrobial agent in a hydric solvent to create an active premix; and   mixing the active premix with the soap.   
     
     
         18 . The process of  claim 17 , wherein the primary nitrogenous base is monoethanolamine, and the secondary acid is lactic acid.