Torque sensitive diaphragm valve

Abstract

This invention relates to pressure torque sanitary diaphragm valves and methods of using torque sensitive sanitary valves in the production of chemical and biological therapeutics to obtain procedural reproducibility in the production pharmaceutical compounds and intermediates related thereto.

1 . A device, comprising: 
 (a) a housing having a flow housing area with a shape for the transfer of solution through said flow housing area and a stem housing area with a first opening attached to said flow housing area;    (b) a stem with a top and a bottom shaped to mate with the shape of said flow housing area:    (c) a slipping mechanism attached to said stem;    (d) a diaphram with a chemical contact side and a stem contact side located in said first opening of said stem housing area between said stem and said flow housing area; and    (e) a handle attached to said slipping mechanism and configured such that said handle slips when said stem bottom compresses said diaphram to form a seal with said flow housing area.