High concentration dinotefuran formulations

Abstract

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.

1 . An insecticide and solvent combination consisting essentially of an insecticidably effective amount of dinotefuran dissolved in an effective amount of a solvent component consisting essentially of ethyl lactate and water or ethyl lactate to dissolve said dinotefuran.  
   
   
       2 . The insecticide and solvent of  claim 1 , wherein said dinotefuran is dissolved in the formulation to a concentration of about 5 to 25%.  
   
   
       3 .- 5 . (canceled)  
   
   
       6 . The insecticide and solvent of  claim 1 , wherein said solvent component comprises over about 35% ethyl lactate.  
   
   
       7 .- 20 . (canceled)  
   
   
       21 . The insecticide and solvent of  claim 1 , wherein the formulation is not irritating to dogs or cats and is effective to kill fleas with applications of less than 20 ml to a cat.  
   
   
       22 . (canceled)  
   
   
       23 . The insecticide and solvent of  claim 1 , wherein 1.0 ml or less of the formulation is effective to kill fleas on a cat for at least one month.  
   
   
       24 .- 26 . (canceled)  
   
   
       27 . The insecticide and solvent of  claim 1 , combined with one or more fragrances, hair conditioners, spreading agents or UV protectants.  
   
   
       28 . (canceled)  
   
   
       29 . A method of controlling insect infestation in animals, comprising dissolving dinotefuran in a solvent composition consisting essentially of ethyl lactate and water or ethyl lactate and applying an insecticidably effective amount of the solution to an animal.  
   
   
       30 . The method of  claim 29 , wherein the animal is a cat or a dog.  
   
   
       31 . The method of  claim 29 , wherein the insect is a flea.  
   
   
       32 . An insecticide formulation consisting essentially of dinotefuran and ethyl lactate or dinotefuran, ethyl lactate and water.  
   
   
       33 . The insecticide formulation of  claim 32 , consisting essentially of dinotefuran and ethyl lactate.