Therapy of estrogen-associated disorders

Abstract

A method for the treatment, prophylaxis, amelioration or prevention of disorders associated with abnormally high activity of steroidal estrogens, which includes administering to a human subject a composition comprising an isoflavone-containing extract of clover or chick peas, said extract comprising primarily biochanin, or a ration of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein in the range of from about 2:1 to about 5:1, optionally in association with one or more pharmaceutically acceptable carriers, excipients, auxiliaries and/or diluents is described. Also described are compositions and uses comprising the isoflavone containing extracts.

1 - 18 . (canceled)  
   
   
       19 . A method for the treatment, prophylaxis, amelioration or prevention of a condition selected from the group consisting of: uterine fibroids, polycystic ovarian disease, ovarian cysts, cyclical acne, mastalgia, endometriosis and endometrial hyperplasia, said method comprising administration of an isoflavone-containing extract of clover or chick pea, or an isoflavone-containing extract of clover or chick pea comprising primarily biochanin and any one or more of the isoflavones from the group formononetin, daidzein and genistein at a ration from about 2:1 to about 5:1  
   
   
       20 . The method according to  claim 19 , wherein the isoflavone-containing extract primarily comprising biochanin comprises at least 65% biochanin by weight, the remainder comprising essentially formononetin and/or daidzein and/or genistein.  
   
   
       21 . The method according to  claim 20 , comprising 70 to 100% biochanin.  
   
   
       22 . The method according to  claim 19 , wherein the ratio of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein is from about 7:3 to about 5:1.  
   
   
       23 . The method according to  claim 19 , wherein the extract of clover or chick pea is a water/water-miscible organic solvent extract.  
   
   
       24 . The method according to  claim 19 , wherein the clover is red clover.  
   
   
       25 . The method according to  claim 19 , wherein the isoflavone is in a glycoside, agylcone, acetyl or malonyl form.  
   
   
       26 . A method for the treatment, prophylaxis, amelioration or prevention of a condition selected from the group consisting of: uterine fibroids, polycystic ovarian disease, ovarian cysts, cyclical acne, mastalgia, endometriosis and endometrial hyperplasia, said method comprising administration of a composition comprising an isoflavone-containing extract of clover or chick pea, or an isoflavone-containing extract of clover or chick pea comprising primarily biochanin, or a ratio of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein in the range of from about 2:1 to about 5:1, optionally in association with one or more pharmaceutically acceptable carriers, excipients, auxiliaries, and/or diluents.  
   
   
       27 . The method according to  claim 26 , wherein the isoflavone-containing extract primarily comprising biochanin comprises at least 65% biochanin by weight, the remainder comprising isoflavones from the group formononetin, daidzein and genistein.  
   
   
       28 . The method according to  claim 27 , comprising 70 to 100% biochanin.  
   
   
       29 . The method according to  claim 26 , wherein the ratio of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein is in the range of from about 7:3 to about 5:1.  
   
   
       30 . The method according to  claim 26 , wherein the isoflavone is in a glycoside, agylcone, acetyl or malonyl form.  
   
   
       31 . The method according to  claim 19 , wherein the condition is polycystic ovarian disease.  
   
   
       32 . The method according to  claim 26 , wherein the condition is polycystic ovarian disease.