Appetite-Suppressing Compositions And Methods

Abstract

The invention relates to appetite-suppressing compositions obtained from botanical sources. More specifically, the invention relates to appetite-suppressing compositions comprising an extract product of an Asclepias plant, methods of making an appetite-suppressing composition, and methods of suppressing an appetite.

1 . An appetite-suppressing composition comprising: 
 an extract product of a plant material of an  Asclepias  plant and at least one of additive selected from the group consisting of diluents, fillers, salts and binders    
   
   
       2 . The appetite-suppressing composition of  claim 1 , wherein the plant material is selected from the group consisting of leaves, stems, flowers, fruits, seeds and roots.  
   
   
       3 . The appetite-suppressing composition of  claim 1 , wherein the plant is selected from the group consisting of  A. incarnata, A. curassavica, A. syriaca  and  A. tuberosa.    
   
   
       4 . The appetite-suppressing composition of  claim 1 , wherein the extract product comprises compounds in accordance with the following formula (I):  
     
       
         
         
             
             
         
       
       wherein R 1  is hydrogen or a C 1 -C 18  moiety;  
       R 2  is hydrogen or a C 1 -C 18  moiety;  
       R 3  is a C 1 -C 18  moiety;  
       R 4  is hydrogen or a C 1 -C 18  moiety;  
       R 5  is hydrogen or a C 1 -C 18  moiety;  
       R 6  is hydrogen, a C 1 -C 18  moiety, or a saccharide moiety; and,  
       the dotted line represents an optional double bond.  
     
   
   
       5 . The appetite-suppressing composition of  claim 1 , wherein the extract product comprises compounds in accordance with the following formula (II):  
     
       
         
         
             
             
         
       
       wherein R 1  is hydrogen or a C 1 -C 18  moiety;  
       R 3  is a C 1 -C 18  moiety;  
       R 4  is hydrogen or a C 1 -C 18  moiety;  
       R 5  is hydrogen or a C 1 -C 18  moiety;  
       R 6  is hydrogen, a C 1 -C 18  moiety, or a saccharide moiety; and,  
       the dotted line represents an optional double bond.  
     
   
   
       6 . The appetite-suppressing composition of  claim 1 , wherein the extract product comprises compounds in accordance with the following formula (III):  
     
       
         
         
             
             
         
       
       wherein R 1  is hydrogen or a C 1 -C 18  moiety;  
       R 2  is hydrogen or a C 1 -C 18  moiety;  
       R 3  is a C 1 -C 18  moiety;  
       R 4  is hydrogen or a C 1 -C 18  moiety;  
       R 6  is hydrogen, a C 1 -C 18  moiety, or a saccharide moiety; and,  
       the dotted line represents an optional double bond.  
     
   
   
       7 . A method of making an appetite-suppressing composition, comprising: 
 providing a plant material of an  Asclepias  plant;    contacting the plant material with a solvent, thereby isolating the appetite-suppressing composition.    
   
   
       8 . The method of  claim 7 , further comprising macerating the plant material.  
   
   
       9 . The method of  claim 7 , wherein the plant material is selected from the group consisting of leaves, stems, flowers, fruits, seeds and roots.  
   
   
       10 . The method of  claim 7 , wherein the plant is selected from the group consisting of  A. incarnata, A. curassavica, A. syriaca  and  A. tuberosa.    
   
   
       11 . The method of  claim 7 , wherein the solvent is selected from the group consisting of water, alcohols, alkanes, halocarbons, ethers, aromatic solvents, ketones, aqueous solvent systems and super critical fluids.  
   
   
       12 . The method of  claim 7 , wherein the extract product comprises compounds in accordance with the following formula (I):  
     
       
         
         
             
             
         
       
       wherein R 1  is hydrogen or a C 1 -C 18  moiety;  
       R 2  is hydrogen or a C 1 -C 18  moiety;  
       R 3  is a C 1 -C 18  moiety;  
       R 4  is hydrogen or a C 1 -C 18  moiety;  
       R 5  is hydrogen or a C 1 -C 18  moiety;  
       R 6  is hydrogen, a C 1 -C 18  moiety, or a saccharide moiety; and,  
       the dotted line represents an optional double bond.  
     
   
   
       13 . The method of  claim 7 , wherein the extract product comprises compounds in accordance with the following formula (II):  
     
       
         
         
             
             
         
       
       wherein R 1  is hydrogen or a C 1 -C 18  moiety;  
       R 3  is a C 1 -C 18  moiety;  
       R 4  is hydrogen or a C 1 -C 18  moiety;  
       R 5  is hydrogen or a C 1 -C 18  moiety;  
       R 6  is hydrogen, a C 1 -C 18  moiety, or a saccharide moiety; and, the dotted line represents an optional double bond.  
     
   
   
       14 . The method of  claim 7 , wherein the extract product comprises compounds in accordance with the following formula (III):  
     
       
         
         
             
             
         
       
       wherein R 1  is hydrogen or a C 1 -C 18  moiety;  
       R 2  is hydrogen or a C 1 -C 18  moiety;  
       R 3  is a C 1 -C 18  moiety;  
       R 4  is hydrogen or a C 1 -C 18  moiety;  
       R 6  is hydrogen, a C 1 -C 18  moiety, or a saccharide moiety; and,  
       the dotted line represents an optional double bond.