Pyrrolobenzodiazepines

Abstract

A compound of formula I: or solvate thereof, wherein n is 1 to 10, and M and M′ are independently selected from monovalent pharmaceutically acceptable cations, or together represent a divalent pharmaceutically acceptable cation.

1 . A compound of formula I:  
       
         
           
           
               
               
           
         
       
       or solvate thereof, wherein n is 1 to 10, and M and M′ are independently selected from monovalent pharmaceutically acceptable cations, or together represent a divalent pharmaceutically acceptable cation.  
     
     
         2 . A compound according to  claim 1 , wherein n is 1, 3, 6, 7 or 8.  
     
     
         3 . A compound according to  claim 2 , wherein n is 1 or 3.  
     
     
         4 . A compound according to  claim 1 , wherein M and Mf are the same.  
     
     
         5 . A compound according to  claim 4 , wherein M and M′ are alkali metal ions.  
     
     
         6 . A compound according to  claim 5 , wherein M and M′ are Na+.  
     
     
         7 . The synthesis of a compound according  claim 1 .  
     
     
         8 . A compound according to  claim 1  for use in a method of therapy.  
     
     
         9 . A pharmaceutical composition comprising a compound according to  claim 1  and a pharmaceutically acceptable excipient.  
     
     
         10 . The use of a compound according to  claim 1  in the manufacture of a medicament for the treatment of a gene based disease.  
     
     
         11 . A method for the treatment of a gene-based disease, comprising administering to a subject suffering from a gene-based disease a therapeutically-effective amount of a compound according to  claim 1.