US2008039478A1PendingUtilityA1

Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof

Assignee: RENOVIS INCPriority: Mar 24, 2005Filed: Jul 3, 2007Published: Feb 14, 2008
Est. expiryMar 24, 2025(expired)· nominal 20-yr term from priority
A61P 3/10A61P 37/08A61P 37/00A61P 7/00A61P 43/00A61P 37/02A61P 3/06A61P 9/10A61P 9/12A61P 9/00A61P 39/02A61P 25/18A61P 29/00A61P 25/06A61P 3/04A61P 25/24A61P 27/16A61P 35/00A61P 3/00A61P 25/02A61P 25/04A61P 25/16A61P 25/22A61P 25/20A61P 27/02A61P 25/28A61P 25/00A61P 25/08A61P 13/08A61P 13/02A61P 13/10C07D 405/06A61P 19/00A61P 11/02A61P 17/02C07D 487/04A61P 11/08C07D 217/24C07D 471/04A61P 1/00A61P 17/06C07D 413/06A61P 1/14A61P 11/06C07D 401/06A61P 11/00A61P 13/12A61P 1/02A61P 19/02A61P 17/00A61P 1/12C07D 417/06A61P 17/16A61P 17/04
62
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Claims

Abstract

Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Claims

exact text as granted — not AI-modified
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         49 . A method for preventing, treating or ameliorating in a mammal a disease or condition that is causally related to the aberrant activity of the P2X 7  receptor in vivo, which comprises administering to the mammal an effective disease-treating or condition-treating amount of a pharmaceutical composition, said pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound having a formula:  
       
         
           
           
               
               
           
         
         wherein  
         A is selected from CR 2a R 2b ;  
         B and Y are independently selected from CR 2a  and CR 2a R 2b ;  
         Z is CR 4 :  
         L 1  is a bond, —CO— —SO 2 — or a C 1 -C 5  alkylene group which can be optionally substituted by a substituent selected from alkyl hydroxy hydroxyalkylaminoalkyl alkylaminoalkyl dialkylaminoalkyl halogen, carbamoyl and C 1 -C 6  alkoxy;  
         n is 0, 1, 2 or 3,  
         R 1  is selected from a 3-13 membered cycloalkyl which can be optionally substituted with one or more substituents independently selected from halo hydroxylamino cyano sulfo sulfanyl, sulfinyl amido, carboxy, ester, alkyl substituted alkyl alkenyl substituted alkenyl alkynyl substituted alkynyl and sulfonamido:  
         each of R 2a , R 2b R 2′  and R 2″  is independently selected from hydrogen, substituted or unsubstituted C 1 -C 6  alkyl; or any of R 2′  and R 2″  can join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms;  
         R 3  is selected from hydrogen substituted or unsubstituted alkyl substituted or unsubstituted cycloalkyl substituted or unsubstituted heterocycloalkyl substituted or unsubstituted aryl substituted or unsubstituted heteroaryl, substituted or unsubstituted bicycloaryl, and substituted or unsubstituted bicycloheteroaryl; provided when R 3  is hydrogen L 1  is a bond or a C 1 -C 5  alkylene group,  
         R 4  is selected from H, alkyl substituted alkyl acyl substituted acyl substituted or unsubstituted acylamino substituted or unsubstituted alkylamino substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, alkoxycarbonyl substituted alkoxycarbonyl substituted or unsubstituted alkylarylamino arylalkyloxy substituted arylalkyloxy amino aryl, substituted aryl, arylalkyl substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone substituted or unsubstituted sulfanyl substituted or unsubstituted aminosulfonyl substituted or unsubstituted arylsulfonyl sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl substituted or unsubstituted aminodihydroxyphosphoryl azido, carboxy, substituted or unsubstituted carbamoyl cyano, substituted or unsubstituted cycloalkyl substituted or unsubstituted cycloheteroalkyl substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio;  
         and the dotted bond is a single or a double bond,  
         or a pharmaceutically acceptable salt thereof,  
         and stereoisomers and tautomers thereof.  
       
     
     
         50 . The method of  claim 49 , wherein the disease or condition is a pain condition.  
     
     
         51 . The method of  claim 49 , wherein the disease or condition is an autoimmune disease.  
     
     
         52 . The method of  claim 49 , wherein the disease or condition is an inflammatory disease or condition.  
     
     
         53 . The method of  claim 49 , wherein the disease or condition is a neurological or neurodegenerative disease or condition.  
     
     
         54 . A method for preventing, treating or ameliorating in a mammal a disease or condition selected from: pain including acute, inflammatory and neuropathic pain, chronic pain, dental pain and headache including migraine, cluster headache and tension headache, Parkinson's disease, multiple sclerosis; diseases and disorders which are mediated by or result in neuroinflammation, traumatic brain injury and encephalitis; centrally-mediated neuropsychiatric diseases and disorders, depression mania, bipolar disease, anxiety, schizophrenia, eating disorders, sleep disorders and cognition disorders; epilepsy and seizure disorders; prostate, bladder and bowel dysfunction, urinary incontinence, urinary hesitancy, rectal hypersensitivity, fecal incontinence, benign prostatic hypertrophy and inflammatory bowel disease; respiratory and airway disease and disorders, allergic rhinitis, asthma and reactive airway disease and chronic obstructive pulmonary disease; diseases and disorders which are mediated by or result in inflammation, arthritis, rheumatoid arthritis and osteoarthritis, myocardial infarction, various autoimmune diseases and disorders, uveitis and atherosclerosis; itch/pruritus, psoriasis; obesity; lipid disorders; cancer; blood pressure; spinal cord injury; and renal disorders which comprises administering to the mammal an effective disease-treating or condition-treating amount of a pharmaceutical composition, 
 said pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound having a formula:                          wherein    A is selected from CR 2a R 2b ;    B and Y are independently selected from CR 2a  and CR 2a R 2b ;    Z is CR 4 :    L 1  is a bond, —CO— —SO 2 — or a C 1 -C 5  alkylene group which can be optionally substituted by a substituent selected from alkyl, hydroxy, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl halogen, carbamoyl and C 1 -C 6  alkoxy;    n is 0, 1, 2 or 3,    R 1  is selected from a 3-13 membered cycloalkyl which can be optionally substituted with one or more substituents independently selected from halo, hydroxyl, amino, cyano, sulfo, sulfanyl, sulfinyl amido, carboxy, ester, alkyl substituted alkyl alkenyl substituted alkenyl alkynyl substituted alkynyl and sulfonamido:    each of R 2a , R 2b , R 2′  and R 2″  is independently selected from hydrogen, substituted or unsubstituted C 1 -C 6  alkyl: or any of R 2′  and R 2″  can join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms;    R 3  is selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl substituted or unsubstituted heterocycloalkyl substituted or unsubstituted aryl substituted or unsubstituted heteroaryl substituted or unsubstituted bicycloaryl and substituted or unsubstituted bicycloheteroaryl; provided when R 3  is hydrogen L 1  is a bond or a C 1 -C 5  alkylene group,    R 4  is selected from H, alkyl substituted alkyl acyl substituted acyl substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, alkoxycarbonyl substituted alkoxycarbonyl substituted or unsubstituted alkylarylamino arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl substituted or unsubstituted aminosulfonyl substituted or unsubstituted arylsulfonyl sulfuric acid sulfuric acid ester substituted or unsubstituted dihydroxyphosphoryl substituted or unsubstituted aminodihydroxyphosphoryl azido carboxy substituted or unsubstituted carbamoyl cyano, substituted or unsubstituted cycloalkyl substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino halo heteroaryloxy substituted or unsubstituted heteroaryl substituted or unsubstituted heteroalkyl hydroxy, nitro, and thio;    and the dotted bond is a single or a double bond,    or a pharmaceutically acceptable salt thereof,    and stereoisomers and tautomers thereof.    
     
     
         55 . The method of  claim 54 , wherein the disease or condition is Parkinson's disease.  
     
     
         56 . The method of  claim 54 , wherein the disease or condition is rheumatoid arthritis.  
     
     
         57 . The method of  claim 54 , wherein the disease or condition is traumatic brain injury.  
     
     
         58 . The method of  claim 54 , wherein the disease or condition is osteoarthritis.  
     
     
         59 . The method of  claim 54 , wherein the disease or condition is pain.  
     
     
         60 . The method of  claim 54 , wherein the disease or condition is neuropathic pain.  
     
     
         61 . A method of treating a mammal suffering from at least one symptom selected from the group consisting of symptoms of exposure to capsaicin, symptoms of burns or irritation due to exposure to heat, symptoms of burns or irritation due to exposure to light, symptoms of burns, bronchoconstriction or irritation due to exposure to tear gas, and symptoms of burns or irritation due to exposure to acid, which comprises administering to the mammal an effective disease-treating or condition-treating amount of a pharmaceutical composition, 
 said pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound having a formula:                          wherein    A is selected from CR 2a R 2b ;    B and Y are independently selected from CR 2a  and CR 2a R 2b ;    Z is CR 4 :    L 1  is a bond, —CO— —SO 2 — or a C 1 -C 5  alkylene group which can be optionally substituted by a substituent selected from alkyl hydroxy hydroxyalkylaminoalkyl alkylaminoalkyl dialkylaminoalkyl halogen, carbamoyl and C 1 -C 6  alkoxy;    n is 0, 1, 2 or 3,    R 1  is selected from a 3-13 membered cycloalkyl which can be optionally substituted with one or more substituents independently selected from halo hydroxylamino cyano sulfo sulfanyl, sulfinyl amido, carboxy, ester, alkyl substituted alkyl alkenyl substituted alkenyl alkynyl substituted alkynyl and sulfonamido:    each of R 2a , R 2b R 2′  and R 2″  is independently selected from hydrogen, substituted or unsubstituted C 1 -C 6  alkyl: or any of R 2  and R 2  can join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms;    R 3  is selected from hydrogen substituted or unsubstituted alkyl substituted or unsubstituted cycloalkyl substituted or unsubstituted heterocycloalkyl substituted or unsubstituted aryl substituted or unsubstituted heteroaryl, substituted or unsubstituted bicycloaryl, and substituted or unsubstituted bicycloheteroaryl; provided when R 3  is hydrogen L 1  is a bond or a C 1 -C 5  alkylene group,    R 4  is selected from H, alkyl substituted alkyl acyl substituted acyl substituted or unsubstituted acylamino substituted or unsubstituted alkylamino substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, alkoxycarbonyl substituted alkoxycarbonyl substituted or unsubstituted alkylarylamino arylalkyloxy substituted arylalkyloxy amino aryl, substituted aryl, arylalkyl substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone substituted or unsubstituted sulfanyl substituted or unsubstituted aminosulfonyl substituted or unsubstituted arylsulfonyl sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl substituted or unsubstituted aminodihydroxyphosphoryl azido, carboxy, substituted or unsubstituted carbamoyl cyano, substituted or unsubstituted cycloalkyl substituted or unsubstituted cycloheteroalkyl substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio;    and the dotted bond is a single or a double bond;    or a pharmaceutically acceptable salt thereof;    and stereoisomers and tautomers thereof.    
     
     
         62 . The method of  claim 61 , wherein the pain is associated with a condition selected from the group consisting of postmastectomy pain syndrome, stump pain, phantom limb pain, oral neuropathic pain, Charcot's pain, toothache, venomous snake bite, spider bite, insect sting, postherpetic neuralgia, diabetic neuropathy, reflex sympathetic dystrophy, trigeminal neuralgia, osteoarthritis, rheumatoid arthritis, fibromyalgis, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, bilateral peripheral neuropathy, causalgia, sciatic neuritis, peripheral neuritis, polyneuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, egniculate neuralgia, glossopharyngial neuralgia, migranous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, mandibular joint neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstruation, cancer, and trauma.  
     
     
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         66 . A method according to any of claims  49 ,  54  or  61 , wherein said compound is selected from  
       
         
           
                 
                 
               
                     
                 
                     
                 
                   Name 
                   STRUCTURE 
                 
                     
                 
                     
                     
                 
                   5,6,7,8-Tetrahydro-pyrido[3,4- d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Pyridin-3-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid cyclohexylmethyl- amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Pyridin-4-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid cyclohexylmethyl- amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(2-Chloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(4-Chloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Pyridin-2-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid cyclohexylmethyl- amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(3-Chloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(4-Methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid cyclohexylmethyl- amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(4-Methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid cyclohexylmethyl-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(4-Methanesulfonyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid cyclohexylmethyl- amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(4-Acetylamino-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid cyclohexylmethyl- amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidine-4-carboxylic acid (1- hydroxy-cycloheptylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidine-4-carboxylic acid (1- hydroxy-3,3-dimethyl- cyclohexylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Benzyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidine-4-carboxylic acid (1-p- tolyl-cyclohexylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(2,4-Difluoro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid (adamantan-1- ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(2,3-Dihydro-benzo[1,4]dioxin-6- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(2-Fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(3-Fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid (aclamantan-1-ytmetnyt)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(3-Methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid (adamantan-1- ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(2-Methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(2-Chloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-(4-Fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidine-4-carboxylic acid (adamantan-1-ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   7-Benzo[1,3]dioxol-5-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidine-4- carboxylic acid (adamantan-1- ylmethyl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-benzyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-methyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-ethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Benzyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-2- cyclohexyl-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Benzyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-2- cycloheptyl-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cyclohexyl-N-(5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-(5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-hydroxy-3- methoxy-propyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-phenethyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- methanesulfonyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-pyridin-3- ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-hydroxy- ethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamlue; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-hydroxy- propyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cyclohexyl-N-(7-ethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cyclohexyl-N-[7-(3-hydroxy-propyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cyclohexyl-N-[7-(2-hydroxy-ethyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dihydroxy- propyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cyclohexyl-N-(7-methyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methoxy- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methyl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5-dimethyl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chioro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methoxy- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-u]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methyl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methoxy-3- methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methoxy- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-cyano- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-pyridin-4- ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methyl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-ethyl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dihydro- benzo[1,4]dioxin-6-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-difluoro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-pyridin-2- ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(4-Acetylamino-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-2-adamantan-1-yl-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-phenyl- propyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1H-indol-5- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-pyridin-2-yl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl- thiophen-2-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1-methyl-1H- imidazol-2-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-phenoxy- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-quinolin-4- ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-tert-butyl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-quinolin-2- ylmethyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- trifluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-phenoxy- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2- trifluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2- difluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- difluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-phenyl- thiophen-2-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-butyl-1H- imidazol-4-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl-3H- imidazol-4-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1H-imidazol- 4-ylmethyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-chloro- thiophen-2-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-cyano-4- fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro-4- methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro-3- methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(6-chloro-2- fluoro-3-methyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-6- fluoro-3-methyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-{4-[(2- hydroxy-ethyl)-methyl-amino]-benzyl}- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,2-difluoro- benzo[1,3]dioxol-4-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-{4-[4-(2-Adamantan-1-yl- acetylamino)-5,8-dihydro-6H- pyrido[3,4-d]pyrimidin-7-ylmethyl]- phenoxy}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-{2-[4-(2-Adamantan-1-yl- acetylamino)-5,8-dihydro-6H- pyrido[3,4-d]pyrimidin-7-ylmethyl]- phenoxy}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-(7-pyridin-3-ylmethyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-(7-pyridin-2-ylmethyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro-4- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-fluoro-2- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro-4- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-imidazol-1- yl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[4-(2-hydroxy- ethoxy)-benzyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(2-hydroxy- ethoxy)-benzyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[3-(2-hydroxy- ethoxy)-benzyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-fluoro-2- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro-3- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro-5- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dihydro- benzofuran-5-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro-3- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro-2- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro-5- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro-5- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro-4- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro-6- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methyl- naphthalen-1-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-isopropoxy- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   (E)-3-{4-[4-(2-Adamantan-1-yl- acetylamino)-5,8-dihydro-6H- pyrido[3,4-d]pyrimidin-7-ylmethyl]- phenyl}-acrylic acid; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- methylsulfanyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-hydroxy-3- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(6-methyl- pyridin-2-ylmethyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro-4- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- cyclopentylmethyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- cyclohexylmethyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-[7-(3-phenyl-propyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-[7-(5-methyl- thiophen-2-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-[7-( 1H-imidazol-4- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-(7-cyclohexylmethyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-(7-cyclopentylmethyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-(7-phenethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Cycloheptyl-N-[7-(4-fluoro-benzyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro-3- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   {4-[4-(2-Adamantan-1-yl-acetylamino)- 5,8-dihydro-6H-pyrido[3,4-d]pyrimidin- 7-ylmethyl]-phenoxy}-acetic acid; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   {2-[4-(2-Adamantan-1-yl-acetylamino)- 5,8-dihydro-6H-pyrido[3,4-d]pyrimidin- 7-ylmethyl]-phenoxy}-acetic acid; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- methanesulfonyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- benzenesulfonyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(toluene-4- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(naphthalene-2- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(quinoline-8- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(propane-1- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-ethanesulfonyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methoxy- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4- dimethoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- phenylmethanesulfonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-dichloro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- trifluoromethoxy-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methyl-3,4- dihydro-2H-benzo[1,4]oxazine-7- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-chloro-1,3- dimethyl-1H-pyrazole-4-sulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl-2- trifluoromethyl-furan-3-sulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl-1- phenyl-1H-pyrazole-4-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethoxy-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methoxy- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1-methyl-1H- imidazole-4-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1,2-dimethyl- 1H-imidazole-4-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-4- cyano-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-cyano- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chioro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5-dimethyl- isoxazole-4-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- methanesulfonylmethanesulfonyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-oxo-2H- chromene-6-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[4-(pyridin-2- yloxy)-benzenesulfonyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[4-(pyridin-3- yloxy)-benzenesulfonyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[4-(pyridin-4- yloxy)-benzenesulfonyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[4-(4-methoxy- phenoxy)-benzenesulfonyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[4-(3,4- dichloro-phenoxy)-benzenesulfonyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[4-(4- trifluoromethyl-phenoxy)- benzenesulfonyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[3-(3,4- dichloro-phenoxy)-benzenesulfonyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4′-methoxy- biphenyl-4-sulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(pyridine-3- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-5- trifluoromethyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5-bis- trifluoromethyl- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- trifluoromethyl- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-dichloro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5-dichloro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethyl- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-p- tolylmethanesulfonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- difluoromethoxy-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-phenoxy- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chloro-4- fluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(biphenyl-2- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2- trifluoromethyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-pyrazol-1- yl-benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4- dimethoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1,3,5- trimethyl-1H-pyrazole-4-sulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(toluene-2- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dihydro- benzo[1,4]dioxine-6-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- trifluoromethyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro-2- fluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5-difluoro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5-dichloro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-chloro-2- fluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,6-difluoro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chloro-4- methyl-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5-dichloro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-difluoro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,6-dichloro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-4- fluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-fluoro-2- methyl-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(propane-2- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methoxy-5- methyl-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5- dimethoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5-dimethyl- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,6-dichloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Acetyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-2- adamantan-1-yl-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-benzoyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(biphenyl-4- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan--yl-N-[7-(2-chloro- pyridine-3-carbonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-propionyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(4-methoxy- phenyl)-acetyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-phenylacetyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- trifluoromethoxy-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-ethyl- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methyl- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-cyclopentyl- propionyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-difluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methoxy- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5,5- trimethyl-hexanoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-diphenylacetyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(pyridine-3- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- cyclopentanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(2,5- dimethoxy-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methoxy- acetyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(4-fluoro- phenyl)-acetyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-cyano- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- cyclohexanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-dichloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5- dimethoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,6-difluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-phenyl- propionyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-phenoxy- acetyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methoxy- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,2-dimethyl- propionyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(3,4- dimethoxy-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methyl- butyryl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-benzyloxy- acetyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-cyano- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-dichloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(quinoxaline-2- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- cyclopropanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(3-methoxy- phenyl)-acetyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,3-dimethyl- butyryl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-cyclopentyl- acetyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(4-chloro- phenoxy)-acetyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(4-chloro- phenyl)-acetyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro-4- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro-5- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2- trifluoromethoxy-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethoxy-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-5- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-6- fluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl-2- phenyl-2H-[1,2,3]triazole-4-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-phenoxy- pyridine-3-carbonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4- dimethoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dihydro- benzo[1,4]dioxine-2-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-difluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methyl- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5-difluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(6-chloro- pyridine-3-carbonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pynmidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dichloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl- isoxazole-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1,5-dimethyl- 1H-pyrazole-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5-dimethyl- 2H-pyrazole-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1-phenyl-5- trifluoromethyl-1H-pyrazole-4- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methyl-5- phenyl-furan-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl-1- phenyl-1H-pyrazole-4-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[5-(4-chloro- phenyl)-2-methyl-furan-3-carbonyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(naphthalene-2- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-methyl- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methoxy- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5-dimethyl- furan-3-carbonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(1-Acetyl-piperidine-4-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-2-adamantan-1-yl- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(isoxazole-5- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5-dimethyl- isoxazole-4-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro- pyridine-4-carbonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(5-methyl- isoxazole-4-carbonyl)-5,6,7,8- tetrahydro-pyndo[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-tert-butyl-5- methyl-2H-pyrazole-3-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-tert-butyl- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[2-(2-bromo- phenyl)-acetyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(quinoline-2- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(pyridine-4- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(pyridine-2- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[1-(2,2,2- trifluoro-acetyl)-pyrrolidine-2- carbonyl]-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methoxy- propionyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(pyrazine-2- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dihydro- benzofuran-5-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-fluoro-4- methoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(quinoxaline-6- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4- dimethoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(chroman-3- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-5- fluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pynmidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,5-dichloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-{7-[1-(2,3- dihydro-benzo[1,4]dioxin-6-yl)-ethyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(9H-fluoren-2- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-dichloro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-dimethyl- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- benzo[1,3]dioxol-5-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-difluoro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chloro-4- fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chloro-4- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pynmlcun-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro-3- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-4- fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-bis- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro-2- fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro-3- fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-benzyloxy- 2-methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   4-{4-[4-(2-Adamantan-1-yl- acetylamino)-5,8-dihydro-6H- pyrido[3,4-d]pyrimidin-7-ylmethyl]-3- methoxy-phenoxy}-butyric acid; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1H-indol-6- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-dihydro- 2H-benzo[b][1,4]dioxepin-7-ylmethyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- benzyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7-benzyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Benzyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-2-(3,5- dimethyl-adamantan-1-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Benzyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-2-(3,5- dimethyl-adamantan-1-yl)- isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Benzyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-2-(3,5,7- trimethyl-adamantan-1-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Benzyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-2-(3,5,7- trimethyl-adamantan-1-yl)- isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   3,5,7-Trimethyl-adamantane-1- carboxylic acid (7-benzyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,4-difluoro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-methyl- benzyl)-5,6,7,o-tetraflyuro-pyrluo[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dihydro- benzo[1,4]dioxin-6-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(1H-indol-6- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-fluoro- benzyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- phenylmethanesulfonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin- yl)-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-chloro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]- isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-difluoro- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]- isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-dichloro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(4-chloro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-a]pyrimiain-4- yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3-methyl- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,4-dichloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,6-difluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-chloro-6- fluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]- isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,5-difluoro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2,3-dichloro- benzoyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-cyclopentyl- acetyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-(7- cyclohexanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-]pyrimidin-4- yl)-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(3,3-dimethyl- butyryl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-Adamantan-1-yl-N-[7-(2-fluoro- benzyl)-5,6,7,8-tetrahydro-pyridol[3,4- d]pyrimidin-4-yl]-isobutyramide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2-Chloro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-ci]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-[7- (2-fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-[7- (2-methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2,3-Dihydro-benzo[1,4]dioxin-6- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-2-(3,5-dimethyl- adamantan-1-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2,4-Difluoro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-ci]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-[7- (1H-indol-6-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-[7- (4-fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-(7- phenylmethanesulfonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(3,4-Dichloro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(4-Chloro- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(3-Chloro-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- adamantan-1-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2,3-Difluoro-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- adamantan-1-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-[7- (3-methyl-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-[7- (3-trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2-Cyclopentyl-acetyl)-5,6,7,8- tetrahydro-pyrido[3,4-ci]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(3,4-Dichloro-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-ci]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-(7-Cyclohexanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2,6-Difluoro-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   2-(3,5-Dimethyl-adamantan-1-yl)-N-[7- (3,3-dimethyl-butyryl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2-Chloro-6-fluoro-benzoyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-z-y,5-dimethyl- adamantan-1-yl)-acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2,5-Difluoro-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-ci]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   N-[7-(2,3-Dichloro-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-u]pyrimidin-4- yl]-2-(3,5-dimethyl-adamantan-1-yl)- acetamide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,6- dichloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- acetyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- benzoyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-pyridine-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- propionyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2-(4- methoxy-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- phenylacetyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- chloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7(3- fluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- trifluoromethoxy-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- ethyl-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7(3- methyl-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- cyclopentyl-propionyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- difluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- methoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (3,5,5-trimethyl-hexanoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- diphenylacetyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- cyclopentanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2- (2,5-dimethoxy-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- methoxy-acetyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2-(4- fluoro-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- cyano-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- cyclohexanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dichloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,5- dimethoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,6- difluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- phenyl-propionyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- phenoxy-acetyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- methoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- fluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,2- dimethyl-propionyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- chloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2- (3,4-dimethoxy-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- methyl-butyryl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- benzyloxy-acetyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- cyano-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- dichloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (quinoxaline-2-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- cyclopropanecarbonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2-(3- methoxy-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7(3,3- dimethyl-butyryl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- cyclopentyl-acetyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2-(4- chloro-phenoxy)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2-(4- chloro-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-ci]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- fluoro-4-trifluoromethyl-benzoyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- fluoro-5-trifluoromethyl-benzoyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- trifluoromethoxy-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- trifluoromethoxy-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- trifluoromethyl-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-5-trifluoromethyl-benzoyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-6-fluoro-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- methyl-2-phenyl-2H-[1,2,3]triazole-4- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- phenoxy-pyridine-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- dimethoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,3- dihydro-benzo[1,4]dioxine-2-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- difluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- methyl-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,5- difluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- fluoro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(6- chloro-pyridine-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,3- dichloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- methyl-isoxazole-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(1,5- dimethyl-1H-pyrazole-3-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- methyl-5-phenyl-ftiran-3-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- methyl-1-phenyl-1H-pyrazole-4- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[5-(4- chloro-phenyl)-2-methyl-furan-3- carbonyl]-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (naphthalene-2-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- methyl-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- methoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,5- dimethyl-thran-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(1- acetyl-piperidine-4-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (isoxazole-5-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-pyridine-4-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- tert-butyl-5-methyl-2H-pyrazole-3- carbonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- tert-butyl-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[2-(2- bromo-phenyl)-acetyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (quinoline-2-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[1- (2,2,2-trifluoro-acetyl)-pyrrolidine-2- carbonyl]-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (pyrazine-2-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,3- dihydro-benzoftiran-5-carbonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- fluoro-4-methoxy-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dimethoxy-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (chroman-3-carbonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-5-fluoro-benzoyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,5- dichloro-benzoyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- methanesulfonyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- benzenesulfonyl-5,6,7,8 -tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (toluene-4-sulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (naphthalene-2-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (quinoline-8-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (propane-1-sulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- ethanesulfonyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- methoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- chloro-benzenesulfonyl)-5,6,7,8 - tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dimethoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- fluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- phenylmethanesulfonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- trifluoromethyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- trifluoromethoxy-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- methyl-3,4-dihydro-2H- benzo[1,4]oxazine-7-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- chloro-1,3-dimethyl-1H-pyrazole-4- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- methyl-1-phenyl-1H-pyrazole-4- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- trifluoromethoxy-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- methoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(1,2- dimethyl-1H-imidazole-4-sulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-4-cyano-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- fluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- cyano-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,5- dimethyl-isoxazole-4-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- methanesulfonylmethanesulfonyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- oxo-2H-chromene-6-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[4- (pyridin-2-yloxy)-benzenesulfonyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[4- (pyridin-3-yloxy)-benzenesulfonyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[4- (pyridin-4-yloxy)-benzenesulfonyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[4-(4- methoxy-phenoxy)-benzenesulfonyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[4-(4- trifluoromethyl-phenoxy)- benzenesulfonyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[3- (3,4-dichloro-phenoxy)- benzenesulfonyl]-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4′- methoxy-biphenyl-4-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (pyridine-3-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-5-trifluoromethyl- benzenesulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7(3,5- bis-trifluoromethyl- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- trifluoromethyl- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- fluoro-phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dichloro-phenylmethanesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dichloro-phenylmethanesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- trifluoromethyl- phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7-p- tolylmethanesulfonyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- chloro-phenylmethanesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- difluoromethoxy-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- phenoxy-benzenesulfonyl)-5,6,7,8 - tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-benzenesulfonyl)-5,6,7,8 - tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- chloro-4-fluoro-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (biphenyl-2-sulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- trifluoromethyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- pyrazol-1-yl-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- dimethoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (1,3,5-trimethyl-1H-pyrazole-4- sulfonyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- trifluoromethoxy-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (toluene-2-sulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,3- dihydro-benzo[1,4]dioxine-6-sulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- trifluoromethyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- chloro-2-fluoro-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,5- difluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,5- dichloro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- chloro-2-fluoro-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,6- difluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- chloro-4-methyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,5- dichloro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- difluoro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,6- dichloro-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-4-fluoro-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- fluoro-2 -methyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (propane-2-sulfonyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- methoxy-5-methyl-benzenesulfonyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,5- dimethoxy-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,5- dimethyl-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- cyano-benzenesulfonyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7- (3,5,5-trimethyl-hexyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,2- diphenyl-ethyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- phenyl-propyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- propyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- cyclohexylmethyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- cyclopropylmethyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- pentyl-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- phenyl-propyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- pyridin-3-ylmethyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(1- methyl-1H-pyrrol-2-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(1H- indol-3-ylmethyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- benzo[1,3]dioxol-5-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- naphthalen-2-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(6- methyl-4-oxo-4H-cbromen-3-ylmethyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- phenoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- bromo-2-methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- dichloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- cyano-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- tert-butyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(6,6- dimethyl-bicyclo[3.1.1]hept-2-en-2- ylmethyl)-5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- dimethylamino-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- phenoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-6-fluoro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7-butyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7-ethyl- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(1- methyl-1H-indol-3-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- ethyl-butyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- methyl-pentyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- methyl-butyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dimethyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- chloro-3,4-dimethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(6- bromo-benzo[1,3]dioxol-5-ylmethyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- benzyloxy-3-methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,3- dihydro-benzo[1,4]dioxin-6-ylmethyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,4- dichloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,3- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- benzyloxy-4-methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- hydroxy-4-methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- bromo-4,5-dimethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- cyano-4-fluoro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- benzo[1,3]dioxol-4-ylmethyl-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- bromo-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- chloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(6- chloro-benzo[1,3]dioxol-5-ylmethyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,2- dimethyl-propyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- chloro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- cyano-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- trifluoromethyl-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- methyl-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- fluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,4- difluoro-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- pyridin-4-ylmethyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- chloro-3-fluoro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- fluoro-4-trifluoromethyl-benzyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(6- bromo-pyridin-3-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- bromo-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- methoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- acetylamino-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- bromo-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(5- bromo-2-fluoro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid (7- cyclopentylmethyl-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl)-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- trifluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- difluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[4-(4- fluoro-benzyloxy)-benzyl]-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- fluoro-4,5-dimethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,6- difluoro-4-methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- ethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid {7-[3-(3- trifluoromethyl-phenoxy)-benzyl]- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl}-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,2- difluoro-benzo[1,3]dioxol-5-ylmethyl)- 5,6,7,8-tetrahydro-pyrido[3,4- d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2- fluoro-5-methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- fluoro-3-methoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- ethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(2,5- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3- trifluoromethoxy-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(3,5- dimethoxy-benzyl)-5,6,7,8-tetrahydro- pyrido[3,4-d]pyrimidin-4-yl]-amide; 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(6- chloro-pyridin-3-ylmethyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide; and 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   Adamantane-1-carboxylic acid [7-(4- chloro-2-fluoro-benzyl)-5,6,7,8- tetrahydro-pyrido[3,4-d]pyrimidin-4- yl]-amide.

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