US2008050395A1PendingUtilityA1

Methods for preparing and delivering adjuvant compositions

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Individually held — no corporate assignee on recordPriority: Jun 19, 2001Filed: Oct 30, 2007Published: Feb 28, 2008
Est. expiryJun 19, 2021(expired)· nominal 20-yr term from priority
Inventors:Jay D. Gerber
A61P 43/00A61P 37/04A61P 1/04A61K 2039/545A61K 2039/5254A61K 2039/543A61K 39/245A61K 2039/55555A61K 39/39A61K 39/12A61K 2039/541C12N 2710/16734A61K 2039/55511A61K 2039/542
56
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Claims

Abstract

Methods are provided for preparing and delivering an adjuvant for vaccines including lecithin and a polymer. The polymer is preferably polyacrylic acid-based and the delivery method involves administering a vaccine, including an antigen and the adjuvant, to a mucosal surface.

Claims

exact text as granted — not AI-modified
1 . A method for delivering a vaccine to a human or an animal mucosally comprising: formulating a vaccine comprising an antigen and an adjuvant comprising lecithin and an acrylic polymer combined together to form a matrix or netlike structure; and administering the vaccine to a mucosal surface.  
   
   
       2 . The method of  claim 1  wherein the vaccine is administered to a mucosal surface selected from the group consisting of oral cavity, gut, nasal, vaginal and rectal mucosal surfaces.  
   
   
       3 . The method of  claim 1  wherein the vaccine is administered to the human or animal by placing the vaccine in a food or a beverage.  
   
   
       4 . The method of  claim 3  wherein the vaccine is administered in a food or a beverage composition in a concentration of from about 0.0001-5.0% by weight.  
   
   
       5 . The method of  claim 4  wherein the vaccine is administered in a food or a beverage in a concentration of from about 0.01-1.0% by weight.  
   
   
       6 . The method of  claim 1  wherein the vaccine is administered in a dosage form selected from the group consisting of tablet, capsule, granule, suspension, solution, suppository, and troche.  
   
   
       7 . The method of  claim 6  wherein the vaccine is administered in a concentration of from about 0.0001-5.0% by weight.  
   
   
       8 . The method of  claim 1  wherein the vaccine is administered in an injectable formulation.  
   
   
       9 . The method of  claim 8  wherein the vaccine is administered in a concentration of from about 0.2-2.0% by weight.  
   
   
       10 - 19 . (canceled)  
   
   
       20 . A method according to  claim 1  wherein the vaccine is administered as a suspension in oil of the adjuvant and lecithin.  
   
   
       21 . A method according to  claim 1  wherein the vaccine is administered as an emulsion of the adjuvant and lecithin and the emulsion includes an emulsifying agent.  
   
   
       22 . A method according to  claim 1  wherein the polymer and lecithin are emulsified prior to administering the vaccine.

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