US2008051564A1PendingUtilityA1
Delivery of pharmaceutical agents via the human insulin receptor
Est. expiryNov 27, 2022(expired)· nominal 20-yr term from priority
A61P 43/00C07K 2317/24A61P 25/00A61K 47/6849A61K 2039/505C07K 16/2869
60
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Claims
Abstract
A humanized murine antibody is provided that binds to the human insulin receptor (HIR). The humanized murine antibody is suitable for use as a Trojan horse to deliver pharmaceutical agents to human organs and tissue that express the HIR. The humanized murine antibody is especially well suited for delivering neuropharmaceutical agents from the blood stream to the brain across the blood brain barrier (BBB). The humanized murine antibody may be genetically fused to the pharmaceutical agent or it may be linked to the pharmaceutical agent using an avidin-biotin conjugation system.
Claims
exact text as granted — not AI-modified1 - 24 . (canceled)
25 . A humanized antibody that binds to the human insulin receptor.
26 . The humanized antibody of claim 1 , wherein the humanized antibody competes with murine antibody 83-14 for binding to the human insulin receptor.Join the waitlist — get patent alerts
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