US2008057025A1PendingUtilityA1

Method for promoting bone formation

51
Individually held — no corporate assignee on recordPriority: Oct 22, 2002Filed: Apr 5, 2007Published: Mar 6, 2008
Est. expiryOct 22, 2022(expired)· nominal 20-yr term from priority
Inventors:Steven Burke
A61P 19/08A61P 19/10A61K 31/74A61K 31/785
51
PatentIndex Score
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Claims

Abstract

Amine polymers, particularly aliphatic amine polymers, are useful in the treatment and prevention of bone disease and in methods for promoting bone formation. Sevelemer, polyallylamine crosslinked with epichlorohydrin, which is sold under the tradename Renagel®, is the preferred polymer used in the invention.

Claims

exact text as granted — not AI-modified
1 - 33 . (canceled)  
     
     
         34 . A method for promoting bone formation in a mammal in need thereof, comprising administering to said mammal a therapeutically effective amount of at least one amine polymer comprised of repeat units having a backbone and an amino group, wherein said mammal is not suffering from hyperparathyroidism, hyperphosphatemia or osteitis fibrosa.  
     
     
         35 . The method of  claim 34  wherein said amino group is pendent from the polymer backbone.  
     
     
         36 . The method of  claim 34  wherein said amino group are part of the polymer backbone.  
     
     
         37 . The method of  claim 34  wherein said amine polymer is an aromatic amine polymer.  
     
     
         38 . The method of  claim 35  wherein said amine polymer is an aromatic amine polymer.  
     
     
         39 . The method of  claim 36  wherein said amine polymer is an aromatic amine polymer.  
     
     
         40 . The method of  claim 34  wherein said amine polymer is aliphatic.  
     
     
         41 . The method of  claim 35  wherein said amine polymer is aliphatic.  
     
     
         42 . The method of  claim 36  wherein said amine polymer is aliphatic.  
     
     
         43 . A method treating osteoporosis in a mammal in need thereof, comprising administering to said mammal a therapeutically effective amount of at least one amine polymer comprised of repeat units having a backbone and an amino group, wherein said mammal is not suffering from hyperparathyroidism, hyperphosphatemia or osteitis fibrosa.  
     
     
         44 . The method of  claim 43  wherein said amino group is pendent from the polymer backbone.  
     
     
         45 . The method of  claim 43  wherein said amino group are part of the polymer backbone.  
     
     
         46 . The method of  claim 43  wherein said amine polymer is an aromatic amine polymer.  
     
     
         47 . The method of  claim 44  wherein said amine polymer is an aromatic amine polymer.  
     
     
         48 . The method of  claim 45  wherein said amine polymer is an aromatic amine polymer.  
     
     
         49 . The method of  claim 43  wherein said amine polymer is aliphatic.  
     
     
         50 . The method of  claim 44  wherein said amine polymer is aliphatic.  
     
     
         51 . The method of  claim 45  wherein said amine polymer is aliphatic.

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