Pharmaceutical Compositions for Inhalation Containing an Anticholinergic, Corticosteroid, and Betamimetic

Abstract

A pharmaceutical composition comprising: (a) an anticholinergic of formula 1 wherein X − is an anion with a single negative charge; (b) a corticosteroid; and (c) a betamimetic, wherein each component (a), (b), and (c) are optionally in the form of the solvates or hydrates thereof, processes for preparing them, and their use in the treatment of respiratory diseases.

1 - 21 . (canceled)  
     
     
         22 . A pharmaceutical composition comprising: 
 (a) an anticholinergic of formula 1                          wherein X −  is an anion with a single negative charge;    (b) a corticosteroid; and    (c) a betamimetic,    wherein each component (a), (b), and (c) is optionally in the form of a solvate or hydrate thereof, and    wherein the pharmaceutical composition is suitable for inhalation and a propellant-containing aerosol composition containing the anticholinergic, the corticosteroid, and the betamimetic in dissolved or dispersed form.    
     
     
         23 . The propellant-containing aerosol composition according to  claim 22 , wherein the propellant gas is a hydrocarbon or halohydrocarbon or a mixture thereof.  
     
     
         24 . The propellant-containing aerosol composition according to  claim 23 , wherein the propellant gas is selected from n-propane, n-butane, isobutane, or the chlorinated and/or fluorinated derivatives of methane, ethane, propane, butane, cyclopropane, or cyclobutane, or a mixture thereof.  
     
     
         25 . The propellant-containing aerosol composition according to  claim 22 , wherein the propellant gas is TG134a, TG227, or a mixture thereof  
     
     
         26 . The propellant-containing aerosol composition according to one of  claims 22  to  25 , further comprising a cosolvent, stabilizer, surfactant, antioxidant, lubricant, or means for adjusting the pH, or mixture thereof.  
     
     
         27 . The propellant-containing aerosol composition according to one of  claims 22  to  25 , wherein the total amount of the anticholinergic, the corticosteroid, and the betamimetic is up to 5 wt.-% of the composition.