US2008064660A1PendingUtilityA1
Modulation of Inflammation Related to Columnar Epithelia
Est. expiryApr 1, 2011(expired)· nominal 20-yr term from priority
C07C 69/734C12P 1/00A61P 29/00C07K 14/705C07C 59/68C07C 59/58A61K 31/216A61K 31/23C07F 7/081A61K 38/00A61K 31/232G01N 33/5047A61K 31/215G01N 33/5088C07K 16/18A61K 31/20C07C 69/732A61K 31/22C07C 69/736C07C 59/48C07C 59/46C07C 59/42C07C 59/56C12R 2001/91C12N 1/00Y02A50/30
55
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Claims
Abstract
This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods for screening for compounds useful in preventing columnar epithelial inflammation.
Claims
exact text as granted — not AI-modified1 . A method for treating a disease or condition associated with columnar epithelial inflammation selected from the group consisting of epithelium of the kidney, stomach, liver, thyroid, trachea, lung, gall bladder, urinary bladder, bile duct, pancreatic duct, testicle, or intestine, in a subject comprising, administering to a subject an effective amount of a lipoxin A4 compound, wherein the lipoxin compound is an analog of natural lipoxin A4, wherein the analog of natural lipoxin A 4 has a longer half-life than natural lipoxin A4.
2 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
3 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
4 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
5 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
6 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
7 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
8 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
9 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
10 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
11 . The method of claim 1 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
12 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
13 . The method of claim 1 , wherein the lipoxin analog is
where R′ is H or CH 3 .
14 . A compound having the formula:
15 . The compound of claim 14 , further comprising a pharmaceutically acceptable carrier.
16 . A compound having the formula:
17 . The compound of claim 16 , further comprising a pharmaceutically acceptable carrier.
18 . A method for modulating inflammation in a subject, comprising
administering to the subject an effective anti-inflammatory amount of a compound having the formula such that inflammation in a subject is modulated.
19 . The method of claim 18 , further comprising a pharmaceutically acceptable carrier.
20 . A method for modulating inflammation in a subject, comprising
administering to the subject an effective anti-inflammatory amount of a compound having the formula such that inflammation in a subject is modulated.
21 . The method of claim 20 , further comprising a pharmaceutically acceptable carrier.Join the waitlist — get patent alerts
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