ISOLATED BOVINE IgG HEAVY CHAIN PROTEIN AND ITS USE AS AN ANTIMICROBIAL

Abstract

A new protein derived from acid hydrolyzed IgG concentrate which has a molecular weight of about 55,000, and is activated by heat within the defined narrow temperature range provides resulting product that has a protective mechanism for bacterial and viral invasion of living cells.

1 . A treated and isolated IgG fraction, comprising: 
 acid hydrolyzed IgG fraction which has been heated for from 15 minutes to 1 hour at a temperature of from 35° C. to 40° C., and thereafter neutralized.    
     
     
         2 . The treated and isolated IgG fraction of  claim 1  which has been hydrolyzed with from 0.1N to 0.2N acid.  
     
     
         3 . The treated and isolated IgG fraction of  claim 2  wherein the acid is selected from the group consisting of hydrochloric acid, phosphoric acid and sulfuric acid.  
     
     
         4 . The treated and isolated IgG fraction of  claim 1  which has a molecular weight of about 55,000.  
     
     
         5 . The treated and isolated IgG fraction of  claim 1  wherein the IgG fraction is derived from the sources selected from the group consisting of bovine or porcine blood or colostrum, egg or whey.  
     
     
         6 . The treated and isolated IgG fraction of  claim 5  wherein the IgG is derived from bovine blood.  
     
     
         7 . The treated and isolated concentrate of  claim 1  which is spray dried.  
     
     
         8 . A method of providing bacterial static and viral static activity, comprising: 
 oral dosing of a mammalian species with an anti-bacterial and antiviral effective amount of a treated and isolated IgG fraction which is acid hydrolyzed, and has been heated from 15 minutes to 1.0 hour at a temperature of 35° C. to 40° C., and thereafter neutralized.    
     
     
         9 . The method of  claim 8  wherein the amount dosed is sufficient to provide a dosage of 0.25 mg/ml in the mammal's gut.  
     
     
         10 . The method of  claim 8  wherein the dose is up to 5 grams/day.