US2008076906A1PendingUtilityA1

Antagonists of neuropilin receptor function and use thereof

Assignee: CHILDRENS MEDICAL CENTERPriority: Dec 9, 1997Filed: Aug 16, 2007Published: Mar 27, 2008

Est. expiryDec 9, 2017(expired)· nominal 20-yr term from priority

Inventors:Michael Klagsbrun Shay Soker Hua Miao Seiji Takashima

C07K 16/28A61K 39/39558C07K 14/71A61K 38/00A61K 48/00C07K 16/2863A61P 35/04

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Claims

Abstract

The present invention relates to antagonists of neuropilin receptor function and use thereof in the treatment of cancer particularly, metastatic cancer and angiogenic diseases.

Claims

exact text as granted — not AI-modified

1 - 17 . (canceled)  
     
     
         18 . An antibody directed against a neuropilin receptor, wherein said antibody specifically inhibits binding of VEGF to the receptor.  
     
     
         19 . The antibody of claim  5 , wherein the neuropilin is NP-1 or NP-2.

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