Compounds useful for treating neurological disorders

Abstract

The invention relates to the use of compounds for the preparation of a medicament for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. The invention additionally relates to a pharmaceutical composition comprising compounds for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration. A method for treating neuropathic pain, migraine, psychiatric disorder and/or neuronal degeneration is also provided.

1 . A method for treating a disease or condition selected from neuropathic pain, migraine, and neuronal degeneration, in a mammal comprising administering to the mammal, a therapeutically effective amount of a compound of formula [A]:  
       
         
           
           
               
               
           
         
       
       as racemic mixtures or as individual stereoisomers or mixtures of racemic and stereoisomers,  
       wherein 
 (i) X is selected from OH and NR 1 R 2 ;  
 (ii) R 1 , R 2  are independently selected from H and C 1 -C 6  alkyl;  
 (iii) n is 0 or 1; and  
 (iv) one of R 3  and R 4 , together with one of R 5  and R 6 , form a cyclopropyl ring, and the other of R 3 , R 4 , R 5  and R 6  is selected from H and C 1 -C 6  alkyl;  
 or a pharmaceutically acceptable salt, a hydrate and a solvate thereof.  
 
     
     
         2 . A method for treating a psychiatric disorder in a mammal comprising administering to the mammal, a therapeutically effective amount of a compound of formula [A] as defined in  claim 1 , with the exclusion of compounds of formula II:  
       
         
           
           
               
               
           
         
       
       wherein R 1  and R 2  are independently selected from H and C 1 -C 6  alkyl.  
     
     
         3 . The method according to  claim 1  wherein said C 1 -C 6  alkyl group is a straight or a branched alkyl group.  
     
     
         4 . The method according to  claim 1 , wherein in a compound of formula [A]: 
 X is selected from OH and NR 1 R 2 ;    R 1 , R 2  are independently selected from H and C 1 -C 6  alkyl; and    one of R 3  and K 4 , together with one of R 5  and R 6 , form a cyclopropyl ring and the other of R 3 , R 4 , R 5  and R 6  is a methyl.    
     
     
         5 . The method according to  claim 4 , wherein the compound is of the structural formula II:  
       
         
           
           
               
               
           
         
       
       wherein R 1  and R 2  are independently selected from 1H and C 1 -C 6  alkyl.  
     
     
         6 . The method according to  claim 5 , wherein at least one of R 1  and R 2  is H and the other of R 1  and R 2  is a C 1 -C 6  alkyl.  
     
     
         7 . The method according to  claim 6 , wherein said C 1 -C 6  alkyl is a methyl.  
     
     
         8 . The method according to  claim 7 , wherein said compound is N-Methyl-2,2,3,3-tetramethylcyclopropanecarboxamide.  
     
     
         9 . The method according to  claim 7 , wherein said compound is 2,2,3,3-tetramethylcyclopropanecarboxamide.  
     
     
         10 . The method according to  claim 7 , wherein said compound is 2,2,3,3-tetramethylcyclopropanecarboxylic acid.  
     
     
         11 . The method according to  claim 1 , wherein said disease or condition is a neuropathic pain.  
     
     
         12 . The method according to  claim 1 , wherein the route of administration of said compound is selected from oral, parenteral, topical, transdermal, mucosal, rectal and buccal administration.  
     
     
         13 . The method according to  claim 12 , wherein the route of administration of said compound is selected from oral and parenteral administration.  
     
     
         14 . The method according to  claim 13 , wherein said parenteral route of administration is selected from intravenous, intramuscular, intraperitoneal and subcutaneous administration.  
     
     
         15 . The method of  claim 1 , wherein said mammal is a human.