Compositions and methods for treatment of non-hodgkin's lymphoma

Abstract

The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.

1 . A method of diagnosing a non-Hodgkin's lymphoma that overexpresses UNQ733, the method comprising determining the level of UNQ733 in a test sample of tissue cells obtained from a non-Hodgkin's lymphoma, wherein a higher level of UNQ733 in the test sample, as compared to a control sample, is indicative of the presence of a non-Hodgkin's lymphoma that overexpresses UNQ733.  
     
     
         2 . The method of  claim 1 , wherein the level of UNQ733 is determined based on the level of UNQ733 RNA in the test sample.  
     
     
         3 . The method of  claim 1 , wherein the level of UNQ733 is determined based on the level of UNQ733 polypeptide in the test sample.  
     
     
         4 . The method of  claim 1 , wherein the non-Hodgkin's lymphoma that overexpresses UNQ733 is a B cell lymphoma, diffuse large B cell lymphoma, follicular lymphoma, small lymphocytic lymphoma, malignant lymphoma, malignant T cell lymphoma, anaplastic large cell lymphoma or mucosal associated lymphoid tissue lymphoma.  
     
     
         5 . The method of  claim 1 , wherein the non-Hodgkin's lymphoma that overexpresses UNQ733 is a T-cell lymphoma.  
     
     
         6 . The method of  claim 1 , wherein the non-Hodgkin's lymphoma that overexpresses UNQ733 is a B-cell lymphoma.  
     
     
         7 . The method of  claim 1 , wherein determining the level of UNQ733 in the test sample comprises exposing the test sample to an antibody that binds to a UNQ733 polypeptide and detecting binding of the antibody to a UNQ733 polypeptide in the test sample.  
     
     
         8 . The method of  claim 7  wherein the antibody is detectably labeled and/or attached to a solid support.