Thrombopoietin activity modulating compounds and methods

Abstract

Disclosed herein are compounds, pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.

1 . An isolated compound that is a TPO receptor agonist and is not a TPO receptor partial agonist.  
     
     
         2 . The compound of  claim 1  that is a selective TPO receptor agonist.  
     
     
         3 . The compound of  claim 1  that is a selective TPO receptor binding compound.  
     
     
         4 . The compound of  claim 1  that is a tissue-specific modulator.  
     
     
         5 . A compound that is a TPO receptor agonist, is not TPO and is not a TPO receptor partial agonist.  
     
     
         6 . The compound of  claim 5  that is a selective TPO receptor agonist.  
     
     
         7 . The compound of  claim 5  that is a selective TPO receptor binding compound.  
     
     
         8 . The compound of  claim 5  that is a tissue-specific modulator.  
     
     
         9 . A method for modulating a TPO activity in a cell comprising contacting a cell with a compound of  claim 1 .  
     
     
         10 . A method for identifying a compound that modulates a TPO activity, comprising contacting a cell that expresses a TPO receptor with a compound of  claim 1;  and monitoring an effect of the compound on the cell.  
     
     
         11 . A method of treating thrombocytopenia in a patient in need thereof with a compound of  claim 1 .  
     
     
         12 . The method of  claim 9 , wherein the thrombocytopenia results from radiation or chemotherapy.  
     
     
         13 . The method of  claim 9 , further comprising harvesting cells from the patient.  
     
     
         14 . A method for modulating a TPO activity in a cell comprising contacting a cell with a compound of  claim 5 .  
     
     
         15 . A method for identifying a compound that modulates a TPO activity, comprising contacting a cell that expresses a TPO receptor with a compound of  claim 5;  and monitoring an effect of the compound on the cell.  
     
     
         16 . A method of treating thrombocytopenia in a patient in need thereof with a compound of  claim 5 .  
     
     
         17 . The method of  claim 14 , wherein the thrombocytopenia results from radiation or chemotherapy.  
     
     
         18 . The method of  claim 14 , further comprising harvesting cells from the patient.  
     
     
         19 . A pharmaceutical composition comprising a compound of  claim 1 .  
     
     
         20 . A pharmaceutical composition comprising a compound of  claim 5.