Intra-aortic renal drug delivery catheter

Abstract

A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.

1 . A system for controlling the flow of blood in a patient, comprising: 
 a shaft having a proximal end, a distal end, and a lumen extending therein;    a tubular member coupled with the distal end of the shaft, the tubular member having a self-expanding frame; and    a restraining member configured to apply a compressive force to the self-expanding frame so as to hold the frame in a low profile configuration;    wherein the tubular member is configured to expand from the low profile configuration to an expanded configuration when the restraining member is removed, such that in the expanded configuration the tubular member provides an interior passageway that extends between a proximal opening of the tubular member and a distal opening of the tubular member; and    wherein the lumen of the shaft comprises an agent delivery lumen, and the agent delivery lumen is in fluid communication with an agent delivery port that is disposed proximal to the distal opening of the tubular member.    
   
   
       2 . The system of  claim 1 , comprising a sheath coupled with the self-expanding frame.  
   
   
       3 . The system of  claim 1 , wherein the fluid agent comprises a vasoactive agent.  
   
   
       4 . The system of  claim 1 , wherein the fluid agent comprises a member selected from the group consisting of Papaverine, a Calcium-channel blocker, Nifedipine, Verapamil, Fenoldapam, and a dopamine DA1 agonist.  
   
   
       5 . The system of  claim 1 , wherein the tubular member comprises a conical shape or a frustroconical shape.  
   
   
       6 . The system of  claim 1 , wherein the tubular member comprises an inflatable member.  
   
   
       7 . The system of  claim 1 , wherein the tubular member comprises a spring force that urges the tubular body to elongate and reduce in diameter.  
   
   
       8 . The system of  claim 1 , wherein the tubular member comprises braided filaments.  
   
   
       9 . The system of  claim 1 , wherein the tubular member comprises an agent delivery opening.  
   
   
       10 . The system of  claim 1 , wherein the shaft comprises an agent delivery port, and the tubular member comprises an agent delivery opening that is adjacent to the agent delivery port.  
   
   
       11 . The system of  claim 1 , wherein the shaft comprises an agent delivery port.  
   
   
       12 . The system of  claim 11 , wherein the agent delivery port is proximal to a distal end of the tubular member.